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Title: Autonomic Function Recovery and Physical Activity Levels in Post-COVID-19 Young Adults after Immunization: An Observational Follow-Up Case-Control Study
Authors: Freire, Ana Paula Coelho Figueira
Amin, Shaan
de Lira, Fábio Santos 
Morano, Ana Elisa von Ah
Pereira, Telmo 
Coelho-e-Silva, Manuel João 
Caseiro, Armando 
Christofaro, Diego Giulliano Destro
Dos Santos, Vanessa Ribeiro
Júnior, Osmar Marchioto
Pinho, Ricardo Aurino
Silva, Bruna Spolador de Alencar
Keywords: COVID-19; SARS-CoV-2; exercise; autonomic nervous system; sympathetic nervous system; parasympathetic nervous system; COVID-19 vaccination; post-acute sequelae of COVID-19; communicable diseases
Issue Date: 27-Jan-2023
Publisher: MDPI
Project: (CNPq)—Brazil and the Coordination for the Improvement of Higher Education Personnel (CAPES)—Brazil (code 001) 
São Paulo Research Foundation (FAPESP)/Brazil 
Serial title, monograph or event: International Journal of Environmental Research and Public Health
Volume: 20
Issue: 3
Abstract: Coronavirus disease 2019 (COVID-19) has detrimental multi-system consequences. Symptoms may appear during the acute phase of infection, but the literature on long-term recovery of young adults after mild to moderate infection is lacking. Heart rate variability (HRV) allows for the observation of autonomic nervous system (ANS) modulation post-SARS-CoV-2 infection. Since physical activity (PA) can help improve ANS modulation, investigating factors that can influence HRV outcomes after COVID-19 is essential to advancements in care and intervention strategies. Clinicians may use this research to aid in the development of non-medication interventions. At baseline, 18 control (CT) and 20 post-COVID-19 (PCOV) participants were observed where general anamnesis was performed, followed by HRV and PA assessment. Thus, 10 CT and 7 PCOV subjects returned for follow-up (FU) evaluation 6 weeks after complete immunization (two doses) and assessments were repeated. Over the follow-up period, a decrease in sympathetic (SNS) activity (mean heart rate: p = 0.0024, CI = -24.67--3.26; SNS index: p = 0.0068, CI = -2.50--0.32) and increase in parasympathetic (PNS) activity (mean RR: p = 0.0097, CI = 33.72-225.51; PNS index: p = 0.0091, CI = -0.20-1.47) were observed. At follow-up, HRV was not different between groups (p > 0.05). Additionally, no differences were observed in PA between moments and groups. This study provides evidence of ANS recovery after SARS-CoV-2 insult in young adults over a follow-up period, independent of changes in PA.
ISSN: 1660-4601
DOI: 10.3390/ijerph20032251
Rights: openAccess
Appears in Collections:I&D CIDAF - Artigos em Revistas Internacionais
FCDEF - Artigos em Revistas Internacionais

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