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Title: Essential Oils from Côa Valley Lamiaceae Species: Cytotoxicity and Antiproliferative Effect on Glioblastoma Cells
Authors: Marques, Mário Pedro 
Neves, Beatriz Guapo 
Varela, Carla Lopes 
Zuzarte, Mónica 
Gonçalves, Ana Cristina 
Dias, Maria Inês
Amaral, Joana S.
Barros, Lillian
Magalhães, Mariana 
Cabral, Célia 
Keywords: essential oils; Lavandula pedunculata; Mentha cervina; Thymus mastichina subsp. mastichina; Côa Valley; cytotoxicity; glioblastoma
Issue Date: 19-Jan-2023
Publisher: MDPI
Project: This research was funded by Foundation for Science and Technology (FCT, Portugal), through the following projects: UIDB/04539/2020, UIDP/04539/2020, and LA/P/0058/2020 (CIBB) Strategic Projects; and COA/BRB/0019/2019 (CoaMedPlants). M.M. is supported by Foundation for Science and Technology (FCT) with a PhD grant (Reference: SFRH/BD/146441/2019). This PhD grant is financed by national budget and co-financed through the European Social Fund (ESF) and the Regional Operational Por_Centro. M.P.M. is supported by Foundation for Science and Technology (FCT) with a PhD grant (Reference: PRT/BD/153391/2021). 
Serial title, monograph or event: Pharmaceutics
Volume: 15
Issue: 2
Abstract: Lavandula pedunculata (Mill.) Cav., Mentha cervina L. and Thymus mastichina (L.) L. subsp. mastichina are representative species of the Côa Valley's flora, a Portuguese UNESCO World Heritage Site. L. pedunculata and T. mastichina are traditionally used to preserve olives and to aromatize bonfires on Saint John's Eve, while M. cervina is mainly used as a spice for river fish dishes. Despite their traditional uses, these aromatic plants are still undervalued, and literature regarding their bioactivity, especially anticancer, is scarce. In this work, the morphology of secretory structures was assessed by scanning electron microscopy (SEM), and the composition of essential oils (EOs) was characterized by gas chromatography-mass spectrometry (GC-MS). The study proceeded with cytotoxic evaluation of EOs in tumor and non-tumor cells with the cell death mechanism explored in glioblastoma (GB) cells. L. pedunculata EO presented the most pronounced cytotoxic/antiproliferative activity against tumor cells, with moderate cytotoxicity against non-tumor cells. Whereas, M. cervina EO exhibited a slightly lower cytotoxic effect against tumor cells and did not affect the viability of non-tumor cells. Meanwhile, T. mastichina EO did not induce a strong cytotoxic effect against GB cells. L. pedunculata and M. cervina EOs lead to cell death by inducing apoptosis in a dose-dependent manner. The present study suggests that L. pedunculata and M. cervina EOs have a strong cytotoxic and antiproliferative potential to be further studied as efficient antitumor agents.
ISSN: 1999-4923
DOI: 10.3390/pharmaceutics15020341
Rights: openAccess
Appears in Collections:I&D CFE - Artigos em Revistas Internacionais
I&D CNC - Artigos em Revistas Internacionais
I&D CIEPQPF - Artigos em Revistas Internacionais
I&D CIBB - Artigos em Revistas Internacionais
I&D ICBR - Artigos em Revistas Internacionais
FMUC Medicina - Artigos em Revistas Internacionais

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