Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/113798
Title: | Zinc: From Biological Functions to Therapeutic Potential | Authors: | Costa, Maria Inês Sarmento-Ribeiro, Ana Bela Gonçalves, Ana Cristina |
Keywords: | zinc signals; zinc transporters; zinc signaling; cell proliferation; cell death; DNA repair; therapeutic target | Issue Date: | 2-Mar-2023 | Publisher: | MDPI | Project: | UID/NEU/04539/2019 UIDB/04539/2020 UIDP/04539/2020 Ph.D. grant (2022.1012.7.BD) |
Serial title, monograph or event: | International Journal of Molecular Sciences | Volume: | 24 | Issue: | 5 | Abstract: | The trace element zinc (Zn) displays a wide range of biological functions. Zn ions control intercellular communication and intracellular events that maintain normal physiological processes. These effects are achieved through the modulation of several Zn-dependent proteins, including transcription factors and enzymes of key cell signaling pathways, namely those involved in proliferation, apoptosis, and antioxidant defenses. Efficient homeostatic systems carefully regulate intracellular Zn concentrations. However, perturbed Zn homeostasis has been implicated in the pathogenesis of several chronic human diseases, such as cancer, diabetes, depression, Wilson's disease, Alzheimer's disease, and other age-related diseases. This review focuses on Zn's roles in cell proliferation, survival/death, and DNA repair mechanisms, outlines some biological Zn targets, and addresses the therapeutic potential of Zn supplementation in some human diseases. | URI: | https://hdl.handle.net/10316/113798 | ISSN: | 1422-0067 | DOI: | 10.3390/ijms24054822 | Rights: | openAccess |
Appears in Collections: | I&D ICBR - Artigos em Revistas Internacionais I&D CIBB - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Zinc-From-Biological-Functions-to-Therapeutic-PotentialInternational-Journal-of-Molecular-Sciences.pdf | 3.01 MB | Adobe PDF | View/Open |
Page view(s)
55
checked on Oct 9, 2024
Download(s)
46
checked on Oct 9, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License