Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/113790
Title: A Hydrophilic Sulfated Resveratrol Derivative for Topical Application: Sensitization and Anti-Allergic Potential
Authors: Jesus, Ana
Sebastião, Ana I. 
Brites, Gonçalo 
Correia-da-Silva, Marta
Cidade, Honorina 
Cruz, Maria T. 
Sousa, Emília
Almeida, Isabel F.
Keywords: resveratrol; sensitization potential; anti-allergic potential; safety profile; cosmetics
Issue Date: 2-Apr-2023
Publisher: MDPI
Project: UIDP/04378/2020 
LA/P/0140/2020 
UIDB/04378/2020 
UIDB/04423/2020 
info:eu-repo/grantAgreement/UIDP/04539/2020 
UIDP/04423/2020 
NORTE-01-0145-FEDER-000040 
CENTRO-01-0145-FEDER-000012 
NORTE-01-0247- FEDER-047239 
UI/BD/151319/2021 
2021.04586.BD 
PD/BDE/142926/2018 
Serial title, monograph or event: Molecules
Volume: 28
Issue: 7
Abstract: Resveratrol (RSV), a naturally occurring metabolite, is widely used in skincare products, but its hydrophobicity impairs its own incorporation into cosmetic formulations. RSV-GS is a synthetic hydrophilic sulfated glycosylated derivative inspired by marine natural products that present a lower cytotoxicity than RSV while exhibiting similar levels of bioactivity. Herein, we predict the skin sensitization potential of this new compound using an in vitro approach based on the OECD 442E guideline. Furthermore, the anti-allergic potential of RSV-GS was also disclosed. The monocyte THP-1 cell line was stimulated with RSV and RSV-GS in the presence or absence of the extreme skin allergen 1-fluoro-2,4-dinitrobenzene (DNFB). The results demonstrated that RSV-GS alone (500 µM) evoked a relative fluorescence index (RFI) lower than the thresholds established by the OECD guideline for CD54 (200%) and CD86 (150%), indicating the absence of a skin sensitization potential. Interestingly, in the presence of the skin allergen DNFB, RSV-GS exhibited the ability to rescue the DNFB-induced maturation of THP-1 cells, with RFI values lower than those for RSV, suggesting the potential of RSV-GS to mitigate skin sensitization evoked by allergens and, consequently, allergic contact dermatitis. These results open new avenues for the use of RSV-GS as a safe and anti-allergic active cosmetic ingredient.
URI: https://hdl.handle.net/10316/113790
ISSN: 1420-3049
DOI: 10.3390/molecules28073158
Rights: openAccess
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais
FFUC- Artigos em Revistas Internacionais

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This item is licensed under a Creative Commons License Creative Commons