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https://hdl.handle.net/10316/113790
Title: | A Hydrophilic Sulfated Resveratrol Derivative for Topical Application: Sensitization and Anti-Allergic Potential | Authors: | Jesus, Ana Sebastião, Ana I. Brites, Gonçalo Correia-da-Silva, Marta Cidade, Honorina Cruz, Maria T. Sousa, Emília Almeida, Isabel F. |
Keywords: | resveratrol; sensitization potential; anti-allergic potential; safety profile; cosmetics | Issue Date: | 2-Apr-2023 | Publisher: | MDPI | Project: | UIDP/04378/2020 LA/P/0140/2020 UIDB/04378/2020 info:eu-repo/grantAgreement/UIDP/04539/2020 UIDP/04423/2020 NORTE-01-0145-FEDER-000040 CENTRO-01-0145-FEDER-000012 NORTE-01-0247- FEDER-047239 info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB/04423/2020 |
Serial title, monograph or event: | Molecules | Volume: | 28 | Issue: | 7 | Abstract: | Resveratrol (RSV), a naturally occurring metabolite, is widely used in skincare products, but its hydrophobicity impairs its own incorporation into cosmetic formulations. RSV-GS is a synthetic hydrophilic sulfated glycosylated derivative inspired by marine natural products that present a lower cytotoxicity than RSV while exhibiting similar levels of bioactivity. Herein, we predict the skin sensitization potential of this new compound using an in vitro approach based on the OECD 442E guideline. Furthermore, the anti-allergic potential of RSV-GS was also disclosed. The monocyte THP-1 cell line was stimulated with RSV and RSV-GS in the presence or absence of the extreme skin allergen 1-fluoro-2,4-dinitrobenzene (DNFB). The results demonstrated that RSV-GS alone (500 µM) evoked a relative fluorescence index (RFI) lower than the thresholds established by the OECD guideline for CD54 (200%) and CD86 (150%), indicating the absence of a skin sensitization potential. Interestingly, in the presence of the skin allergen DNFB, RSV-GS exhibited the ability to rescue the DNFB-induced maturation of THP-1 cells, with RFI values lower than those for RSV, suggesting the potential of RSV-GS to mitigate skin sensitization evoked by allergens and, consequently, allergic contact dermatitis. These results open new avenues for the use of RSV-GS as a safe and anti-allergic active cosmetic ingredient. | URI: | https://hdl.handle.net/10316/113790 | ISSN: | 1420-3049 | DOI: | 10.3390/molecules28073158 | Rights: | openAccess |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais FFUC- Artigos em Revistas Internacionais |
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A-Hydrophilic-Sulfated-Resveratrol-Derivative-for-Topical-Application-Sensitization-and-AntiAllergic-PotentialMolecules.pdf | 1.47 MB | Adobe PDF | View/Open |
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