Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/113732
Title: The Benson Complex Figure Test detects deficits in visuoconstruction and visual memory in symptomatic familial frontotemporal dementia: A GENFI study
Authors: Jiskoot, Lize C.
Russell, Lucy L.
Peakman, Georgia
Convery, Rhian S.
Greaves, Caroline V.
Bocchetta, Martina
Poos, Jackie M.
Seelaar, Harro
Giannini, Lucia A. A.
van Swieten, John C.
van Minkelen, Rick
Pijnenburg, Yolande A. L.
Rowe, James B.
Borroni, Barbara
Galimberti, Daniela
Masellis, Mario
Tartaglia, Carmela
Finger, Elizabeth
Butler, Chris R.
Graff, Caroline
Laforce, Robert
Sánchez-Valle, Raquel 
de Mendonça, Alexandre
Moreno, Fermin
Synofzik, Matthis
Vandenberghe, Rik
Ducharme, Simon
le Ber, Isabelle
Levin, Johannes
Otto, Markus
Pasquier, Florence
Santana, Isabel 
Cash, David M.
Thomas, David
Rohrer, Jonathan D. 
Keywords: Frontotemporal dementia; Cognition; Neuropsychology; Genetic; Presymptomatic; Marker
Issue Date: 15-Mar-2023
Publisher: Elsevier
Project: The Dementia Research Centre is supported by Alzheimer’s Research UK, Alzheimer’s Society, Brain Research UK, and The Wolfson Foundation. This work was supported by the NIHR UCL/H Biomedical Research Centre, the Leonard Wolfson Experimental Neurology Centre (LWENC) Clinical Research Facility, and the UK Dementia Research Institute, which receives its funding from UK DRI Ltd., funded by the UK Medical Research Council, Alzheimer’s Society and Alzheimer’s Research UK. JDR is supported by the Miriam Marks Brain Research UK Senior Fellowship and has received funding from an MRC Clinician Scientist Fellowship (MR/M008525/1) and the NIHR Rare Disease Translational Research Collaboration (BRC149/NS/MH). This work was also supported by the MRC UK GENFI grant (MR/M023664/1), the Bluefield Project, the JPND GENFI-PROX grant (2019–02248), the Dioraphte Foundation [grant numbers 09–02-00], the Association for Frontotemporal Dementias Research Grant 2009, The Netherlands Organization for Scientific Research (NWO) (grant HCMI 056–13-018), ZonMw Memorabel (Deltaplan Dementie; project numbers 733050103 and 733050813), JPND PreFrontAls Consortium (project number 733051042) and Instituto de Salud Carlos III, Spain, and FEDER funds (grant number 20/00448). JBR is supported by the Wellcome Trust (103838), Medical Research Council (SUAG092 G116768) and the NIHR Cambridge Biomedical Research Centre (BRC-1215 􀀀 20014: the views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care). This work was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy within the framework of the Munich Cluster for Systems Neurology (EXC 2145 SyNergy – ID 390857198). JMP is supported by a fellowship award from Alzheimer Nederland (WE.15–2019.02). This work was conducted using the MRC Dementias Platform UK (MR/L023784/1 and MR/009076/1). 
Serial title, monograph or event: Journal of the Neurological Sciences
Volume: 446
Abstract: Sensitive cognitive markers are still needed for frontotemporal dementia (FTD). The Benson Complex Figure Test (BCFT) is an interesting candidate test, as it assesses visuospatial, visual memory, and executive abilities, allowing the detection of multiple mechanisms of cognitive impairment. To investigate differences in BCFT Copy, Recall and Recognition in presymptomatic and symptomatic FTD mutation carriers, and to explore its cognitive and neuroimaging correlates.
URI: https://hdl.handle.net/10316/113732
ISSN: 0022510X
DOI: 10.1016/j.jns.2023.120590
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais

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