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Title: Home-Based Preoperative Exercise Training for Lung Cancer Patients Undergoing Surgery: A Feasibility Trial
Authors: Machado, Pedro 
Pimenta, Sara
Garcia, Ana Luís
Nogueira, Tiago
Silva, Sónia
Oliveiros, Bárbara 
Martins, Raul A. 
Cruz, Joana
Keywords: prehabilitation; exercise training; lung cancer; surgical oncology; quality of life; feasibility; physical activity
Issue Date: 19-Apr-2023
Publisher: MDPI
Project: UIDB/05704/2020 
Serial title, monograph or event: Journal of Clinical Medicine
Volume: 12
Issue: 8
Abstract: Background: Clinical guidelines recommend prehabilitation with exercise training to optimize recovery after lung cancer surgery. However, the lack of access to facility-based exercise programs is a major barrier to routine participation. This study aimed to assess the feasibility of a home-based exercise intervention before lung cancer resection. Methods: We conducted a prospective, two-site feasibility study, including patients scheduled for lung cancer surgery. Exercise prescription involved aerobic and resistance training with telephone-based supervision. The primary endpoint was overall feasibility (recruitment rate, retention rate, intervention adherence and acceptability). Secondary endpoints included safety and effects on health-related quality of life (HRQOL) and physical performance, evaluated at baseline, after the exercise intervention and 4–5 weeks after surgery. Results: Over three months, 15 patients were eligible, and all agreed to participate (recruitment rate: 100%). A total of 14 patients completed the exercise intervention, and 12 patients were evaluated postoperatively (retention rate: 80%). The median length of the exercise intervention was 3 weeks. Patients performed an aerobic and resistance training volume higher than prescribed (median adherence rates of 104% and 111%, respectively). A total of nine adverse events occurred during the intervention (Grade 1, n = 8; Grade 2, n = 1), the most common being shoulder pain. After the exercise intervention, significant improvements were observed in the HRQOL summary score (mean difference, 2.9; 95% confidence interval [CI], from 0.9 to 4.8; p = 0.049) and the five-times sit-to-stand test score (median difference, 􀀀1.5; 95% CI, from 􀀀2.1 to 􀀀0.9; p = 0.001). After surgery, no significant effects on HRQOL and physical performance were observed. Conclusion: A short-term preoperative home-based exercise intervention is feasible before lung cancer resection and may enhance accessibility to prehabilitation. Clinical effectiveness should be investigated in future studies.
ISSN: 2077-0383
DOI: 10.3390/jcm12082971
Rights: openAccess
Appears in Collections:I&D CIBIT - Artigos em Revistas Internacionais
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