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Title: | Mitochondria as biological targets for stem cell and organismal senescence | Authors: | Branco, Ana Moniz, Inês Santos, João Ramalho |
Keywords: | Mesenchymal stem cell; Aging; Mitochondria | Issue Date: | Jun-2023 | Publisher: | Elsevier | Project: | A.F.B. and I.M. were funded by Fundaç˜ao para a Ciˆencia e Tecnologia (FCT) Portugal under a CEEC contract (CEECIND/00860/2018) and a PhD fellowship (2022.10535.BD), respectively. Additional funding was provided by the STEM@REST Project (CENTRO-01-0145-FEDER- 028871) and by the European Regional Development Fund (ERDF), through the Centro 2020 Regional Operational Programme: project CENTRO-01-0145-FEDER-000012-HealthyAging2020, the COMPETE 2020—Operational Programme for Competitiveness and Internationalisation, and the Portuguese national funds via FCT—Fundaç˜ao para a Ciˆencia e a Tecnologia, I.P. through the Strategic Projects POCI-01- 0145-FEDER-007440 and UID/NEU/04539/2020. | Serial title, monograph or event: | European Journal of Cell Biology | Volume: | 102 | Issue: | 2 | Abstract: | Organismal aging is impacted by the deterioration of tissue turnover mechanisms due, in part, to the decline in stem cell function. This decline can be related to mitochondrial dysfunction and underlying energetic defects that, in concert, help drive biological aging. Thus, mitochondria have been described as a potential interventional target to hinder the loss of stem cell robustness, and subsequently, decrease tissue turnover decline and age-associated pathologies. In this review, we focused our analysis on the most recent literature on mitochondria and stem cell aging and discuss the potential benefits of targeting mitochondria in preventing stem cell dysfunction and thus influencing aging. | URI: | https://hdl.handle.net/10316/113184 | ISSN: | 01719335 | DOI: | 10.1016/j.ejcb.2023.151289 | Rights: | openAccess |
Appears in Collections: | FCTUC Ciências da Vida - Artigos em Revistas Internacionais IIIUC - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais |
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Mitochondria as biological targets for stem cell and organismal senescence.pdf | 1.19 MB | Adobe PDF | View/Open |
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