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https://hdl.handle.net/10316/113150
Título: | Reorganization of functional brain network architecture in chronic osteoarthritis pain | Autor: | Barroso, Joana Wakaizumi, Kenta Reis, Ana Mafalda Baliki, Marwan Schnitzer, Thomas J Galhardo, Vasco Apkarian, Apkar Vania |
Palavras-chave: | brain networks; brain topology; chronic pain; graph properties; osteoarthritis | Data: | Mar-2021 | Editora: | Wiley | Título da revista, periódico, livro ou evento: | Human Brain Mapping | Volume: | 42 | Número: | 4 | Resumo: | Osteoarthritis (OA) manifests with chronic pain, motor impairment, and proprioceptive changes. However, the role of the brain in the disease is largely unknown. Here, we studied brain networks using the mathematical properties of graphs in a large sample of knee and hip OA (KOA, n = 91; HOA, n = 23) patients. We used a robust validation strategy by subdividing the KOA data into discovery and testing groups and tested the generalizability of our findings in HOA. Despite brain global topological properties being conserved in OA, we show there is a network wide pattern of reorganization that can be captured at the subject-level by a single measure, the hub disruption index. We localized reorganization patterns and uncovered a shift in the hierarchy of network hubs in OA: primary sensory and motor regions and parahippocampal gyrus behave as hubs and insular cortex loses its central placement. At an intermediate level of network structure, frontoparietal and cingulo-opercular modules showed preferential reorganization. We examined the association between network properties and clinical correlates: global disruption indices and isolated degree properties did not reflect clinical parameters; however, by modeling whole brain nodal degree properties, we identified a distributed set of regions that reliably predicted pain intensity in KOA and generalized to hip OA. Together, our findings reveal that while conserving global topological properties, brain network architecture reorganizes in OA, at both global and local scale. Network connectivity related to OA pain intensity is dissociated from the major hub disruptions, challenging the extent of dependence of OA pain on nociceptive signaling. | URI: | https://hdl.handle.net/10316/113150 | ISSN: | 1065-9471 1097-0193 |
DOI: | 10.1002/hbm.25287 | Direitos: | openAccess |
Aparece nas coleções: | I&D CEIS20 - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Human Brain Mapping - 2020 - Barroso - Reorganization of functional brain network architecture in chronic osteoarthritis.pdf | 5.25 MB | Adobe PDF | Ver/Abrir |
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