Utilize este identificador para referenciar este registo: https://hdl.handle.net/10316/113008
Título: TrkC Intracellular Signalling in the Brain Fear Network During the Formation of a Contextual Fear Memory
Autor: Silva, Francisca 
Masella, Gianluca
Madeira, Maria Francisca 
Duarte, Carlos B. 
Santos, Mónica 
Palavras-chave: Fear conditioning; Neurotrophin 3; Erk; Akt; PLC
Data: Jun-2023
Editora: Springer Nature
Projeto: Bial Foundation [grant 85/18] 
PT2020- Centro 2020 [grant CENTRO-01–0145-FEDER-000008] 
FCT PhD fellowship 2021.06144.BD 
FCT PhD fellowship 2022.13190.BD 
Título da revista, periódico, livro ou evento: Molecular Neurobiology
Volume: 60
Número: 6
Resumo: Learned fear is orchestrated by a brain fear network that comprises the amygdala, hippocampus and the medial prefrontal cortex. Synaptic plasticity within this network is critical for the formation of proper fear memories. Known for their role in the promotion of synaptic plasticity, neurotrophins position as obvious candidates in the regulation of fear processes. Indeed, recent evidence from our laboratory and others associates dysregulated signalling through neurotrophin-3 and its receptor TrkC with the pathophysiology of anxiety and fear-related disorders. Here, we put wild-type C57Bl/6J mice through a contextual fear conditioning paradigm in order to characterize TrkC activation and expression in the main brain regions involved in (learned) fear - amygdala, hippocampus, and prefrontal cortex - during the formation of a fear memory. We report an overall decreased activation of TrkC in the fear network during fear consolidation and reconsolidation. During reconsolidation, hippocampal TrkC downregulation was accompanied by a decrease in the expression and activation of Erk, a critical signalling pathway in fear conditioning. Moreover, we did not find evidence that the observed decrease of TrkC activation was caused by altered expression of dominant negative form of TrkC, neurotrophin-3, or the PTP1B phosphatase. Our results indicate hippocampal TrkC inactivation through Erk signalling as a potential mechanism in the regulation of contextual fear memory formation.
URI: https://hdl.handle.net/10316/113008
ISSN: 0893-7648
1559-1182
DOI: 10.1007/s12035-023-03292-0
Direitos: openAccess
Aparece nas coleções:FCTUC Ciências da Vida - Artigos em Revistas Internacionais
IIIUC - Artigos em Revistas Internacionais
I&D CNC - Artigos em Revistas Internacionais

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