Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/112635
Title: Monocytes in the Characterization of Pain in Palliative Patients with Severe Dementia-A Pilot Study
Authors: Ribeiro, Hugo 
Alves, Raquel 
Jorge, Joana 
Gonçalves, Ana Cristina 
Sarmento-Ribeiro, Ana Bela 
Veríssimo, Manuel T. 
Andrade, José Paulo
Dourado, Marília 
Keywords: monocytes; biomarkers; chronic pain; dementia; pain characterization
Issue Date: 27-Jun-2023
Publisher: MDPI
Project: UIDB/4255/2020 
LA/P/0053/2020 
Serial title, monograph or event: International Journal of Molecular Sciences
Volume: 24
Issue: 13
Abstract: In assessing and managing pain, when obtaining a self-report is impossible, therapeutic decision-making becomes more challenging. This study aimed to investigate whether monocytes and some membrane monocyte proteins, identified as a cluster of differentiation (CD), could be potential non-invasive peripheral biomarkers in identifying and characterizing pain in patients with severe dementia. We used 53 blood samples from non-oncological palliative patients, 44 patients with pain (38 of whom had dementia) and 0 without pain or dementia (controls). We evaluated the levels of monocytes and their subtypes, including classic, intermediate, and non-classic, and characterized the levels of specific phenotypic markers, namely CD11c, CD86, CD163, and CD206. We found that the relative concentrations of monocytes, particularly the percentage of classic monocytes, may be a helpful pain biomarker. Furthermore, the CD11c expression levels were significantly higher in patients with mixed pain, while CD163 and CD206 expression levels were significantly higher in patients with nociceptive pain. These findings suggest that the levels of monocytes, particularly the classic subtype, and their phenotype markers CD11c, CD163, and CD206 could serve as pain biomarkers in patients with severe dementia.
URI: https://hdl.handle.net/10316/112635
ISSN: 1422-0067
DOI: 10.3390/ijms241310723
Rights: openAccess
Appears in Collections:I&D CIBB - Artigos em Revistas Internacionais
I&D ICBR - Artigos em Revistas Internacionais
FMUC Medicina - Artigos em Revistas Internacionais

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