Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/112635
DC FieldValueLanguage
dc.contributor.authorRibeiro, Hugo-
dc.contributor.authorAlves, Raquel-
dc.contributor.authorJorge, Joana-
dc.contributor.authorGonçalves, Ana Cristina-
dc.contributor.authorSarmento-Ribeiro, Ana Bela-
dc.contributor.authorVeríssimo, Manuel T.-
dc.contributor.authorAndrade, José Paulo-
dc.contributor.authorDourado, Marília-
dc.date.accessioned2024-02-02T09:10:39Z-
dc.date.available2024-02-02T09:10:39Z-
dc.date.issued2023-06-27-
dc.identifier.issn1422-0067pt
dc.identifier.urihttps://hdl.handle.net/10316/112635-
dc.description.abstractIn assessing and managing pain, when obtaining a self-report is impossible, therapeutic decision-making becomes more challenging. This study aimed to investigate whether monocytes and some membrane monocyte proteins, identified as a cluster of differentiation (CD), could be potential non-invasive peripheral biomarkers in identifying and characterizing pain in patients with severe dementia. We used 53 blood samples from non-oncological palliative patients, 44 patients with pain (38 of whom had dementia) and 0 without pain or dementia (controls). We evaluated the levels of monocytes and their subtypes, including classic, intermediate, and non-classic, and characterized the levels of specific phenotypic markers, namely CD11c, CD86, CD163, and CD206. We found that the relative concentrations of monocytes, particularly the percentage of classic monocytes, may be a helpful pain biomarker. Furthermore, the CD11c expression levels were significantly higher in patients with mixed pain, while CD163 and CD206 expression levels were significantly higher in patients with nociceptive pain. These findings suggest that the levels of monocytes, particularly the classic subtype, and their phenotype markers CD11c, CD163, and CD206 could serve as pain biomarkers in patients with severe dementia.pt
dc.language.isoengpt
dc.publisherMDPIpt
dc.relationUIDB/4255/2020pt
dc.relationLA/P/0053/2020pt
dc.rightsopenAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt
dc.subjectmonocytespt
dc.subjectbiomarkerspt
dc.subjectchronic painpt
dc.subjectdementiapt
dc.subjectpain characterizationpt
dc.subject.meshHumanspt
dc.subject.meshPilot Projectspt
dc.subject.meshAntigens, Differentiation, Myelomonocyticpt
dc.subject.meshBiomarkerspt
dc.subject.meshMembrane Proteinspt
dc.subject.meshPainpt
dc.subject.meshMonocytespt
dc.subject.meshDementiapt
dc.titleMonocytes in the Characterization of Pain in Palliative Patients with Severe Dementia-A Pilot Studypt
dc.typearticle-
degois.publication.firstPage10723pt
degois.publication.issue13pt
degois.publication.titleInternational Journal of Molecular Sciencespt
dc.peerreviewedyespt
dc.identifier.doi10.3390/ijms241310723pt
degois.publication.volume24pt
dc.date.embargo2023-06-27*
uc.date.periodoEmbargo0pt
item.cerifentitytypePublications-
item.languageiso639-1en-
item.fulltextCom Texto completo-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypearticle-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.orcid0000-0003-2599-6433-
crisitem.author.orcid0000-0003-1470-4802-
crisitem.author.orcid0000-0002-4142-4841-
crisitem.author.orcid0000-0002-2793-2129-
crisitem.author.orcid0000-0002-5003-4722-
Appears in Collections:I&D CIBB - Artigos em Revistas Internacionais
I&D ICBR - Artigos em Revistas Internacionais
FMUC Medicina - Artigos em Revistas Internacionais
Show simple item record

Page view(s)

35
checked on May 22, 2024

Download(s)

10
checked on May 22, 2024

Google ScholarTM

Check

Altmetric

Altmetric


This item is licensed under a Creative Commons License Creative Commons