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Title: Recent Advances in Extracellular Vesicles in Amyotrophic Lateral Sclerosis and Emergent Perspectives
Authors: Afonso, Gonçalo
Cavaleiro, Carla 
Valero, Jorge 
Mota, Sandra 
Ferreiro, E. 
Keywords: amyotrophic lateral sclerosis; neurodegenerative diseases; extracellular vesicles; exosomes; miRNA; biomarkers
Issue Date: 1-Jul-2023
Publisher: MDPI
Project: This work was financed by the European Regional Development Fund (ERDF) through the Centro 2020 Regional Operational Programme and through the COMPETE 2020—Operational Programme for Competitiveness and Internationalisation and Portuguese national funds via FCT— Fundação para a Ciência e a Tecnologia, under projects PTDC/BTM-ORG/0055/2021, UIDB/04539/ 2020, UIDP/04539/2020, and LA/P/0058/2020. CC was supported by FCT (Ref: 2022.13281.BD). S.I.M. was supported by FCT (Ref: DL57/2016/CP1448/CT0027). G.J.M.A. was supported by FCT under a fellowship from project PTDC/BTM-ORG/0055/2021. E.F. was supported by FCT under CEECIND/00322/2017 and 2022.00011.CEECIND. 
Serial title, monograph or event: Cells
Volume: 12
Issue: 13
Abstract: Amyotrophic lateral sclerosis (ALS) is a severe and incurable neurodegenerative disease characterized by the progressive death of motor neurons, leading to paralysis and death. It is a rare disease characterized by high patient-to-patient heterogeneity, which makes its study arduous and complex. Extracellular vesicles (EVs) have emerged as important players in the development of ALS. Thus, ALS phenotype-expressing cells can spread their abnormal bioactive cargo through the secretion of EVs, even in distant tissues. Importantly, owing to their nature and composition, EVs' formation and cargo can be exploited for better comprehension of this elusive disease and identification of novel biomarkers, as well as for potential therapeutic applications, such as those based on stem cell-derived exosomes. This review highlights recent advances in the identification of the role of EVs in ALS etiopathology and how EVs can be promising new therapeutic strategies.
ISSN: 2073-4409
DOI: 10.3390/cells12131763
Rights: openAccess
Appears in Collections:IIIUC - Artigos em Revistas Internacionais
I&D CIBB - Artigos em Revistas Internacionais
I&D CNC - Artigos em Revistas Internacionais

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