Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/112590
Title: Recent Advances in Extracellular Vesicles in Amyotrophic Lateral Sclerosis and Emergent Perspectives
Authors: Afonso, Gonçalo
Cavaleiro, Carla 
Valero, Jorge 
Mota, Sandra 
Ferreiro, E. 
Keywords: amyotrophic lateral sclerosis; neurodegenerative diseases; extracellular vesicles; exosomes; miRNA; biomarkers
Issue Date: 1-Jul-2023
Publisher: MDPI
Project: PTDC/BTM-ORG/0055/2021 
UIDB/04539/2020 
info:eu-repo/grantAgreement/UIDP/04539/2020 
LA/P/0058/2020 
2022.13281.BD 
DL57/2016/CP1448/CT0027 
PTDC/BTM-ORG/0055/2021 
CEECIND/00322/2017 
2022.00011.CEECIND 
Serial title, monograph or event: Cells
Volume: 12
Issue: 13
Abstract: Amyotrophic lateral sclerosis (ALS) is a severe and incurable neurodegenerative disease characterized by the progressive death of motor neurons, leading to paralysis and death. It is a rare disease characterized by high patient-to-patient heterogeneity, which makes its study arduous and complex. Extracellular vesicles (EVs) have emerged as important players in the development of ALS. Thus, ALS phenotype-expressing cells can spread their abnormal bioactive cargo through the secretion of EVs, even in distant tissues. Importantly, owing to their nature and composition, EVs' formation and cargo can be exploited for better comprehension of this elusive disease and identification of novel biomarkers, as well as for potential therapeutic applications, such as those based on stem cell-derived exosomes. This review highlights recent advances in the identification of the role of EVs in ALS etiopathology and how EVs can be promising new therapeutic strategies.
URI: https://hdl.handle.net/10316/112590
ISSN: 2073-4409
DOI: 10.3390/cells12131763
Rights: openAccess
Appears in Collections:IIIUC - Artigos em Revistas Internacionais
I&D CIBB - Artigos em Revistas Internacionais
I&D CNC - Artigos em Revistas Internacionais

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