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Title: | Recent Advances in Extracellular Vesicles in Amyotrophic Lateral Sclerosis and Emergent Perspectives | Authors: | Afonso, Gonçalo Cavaleiro, Carla Valero, Jorge Mota, Sandra Ferreiro, E. |
Keywords: | amyotrophic lateral sclerosis; neurodegenerative diseases; extracellular vesicles; exosomes; miRNA; biomarkers | Issue Date: | 1-Jul-2023 | Publisher: | MDPI | Project: | PTDC/BTM-ORG/0055/2021 UIDB/04539/2020 info:eu-repo/grantAgreement/UIDP/04539/2020 LA/P/0058/2020 2022.13281.BD DL57/2016/CP1448/CT0027 PTDC/BTM-ORG/0055/2021 CEECIND/00322/2017 2022.00011.CEECIND |
Serial title, monograph or event: | Cells | Volume: | 12 | Issue: | 13 | Abstract: | Amyotrophic lateral sclerosis (ALS) is a severe and incurable neurodegenerative disease characterized by the progressive death of motor neurons, leading to paralysis and death. It is a rare disease characterized by high patient-to-patient heterogeneity, which makes its study arduous and complex. Extracellular vesicles (EVs) have emerged as important players in the development of ALS. Thus, ALS phenotype-expressing cells can spread their abnormal bioactive cargo through the secretion of EVs, even in distant tissues. Importantly, owing to their nature and composition, EVs' formation and cargo can be exploited for better comprehension of this elusive disease and identification of novel biomarkers, as well as for potential therapeutic applications, such as those based on stem cell-derived exosomes. This review highlights recent advances in the identification of the role of EVs in ALS etiopathology and how EVs can be promising new therapeutic strategies. | URI: | https://hdl.handle.net/10316/112590 | ISSN: | 2073-4409 | DOI: | 10.3390/cells12131763 | Rights: | openAccess |
Appears in Collections: | IIIUC - Artigos em Revistas Internacionais I&D CIBB - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais |
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