Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/112590
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dc.contributor.authorAfonso, Gonçalo-
dc.contributor.authorCavaleiro, Carla-
dc.contributor.authorValero, Jorge-
dc.contributor.authorMota, Sandra-
dc.contributor.authorFerreiro, E.-
dc.date.accessioned2024-02-01T11:46:19Z-
dc.date.available2024-02-01T11:46:19Z-
dc.date.issued2023-07-01-
dc.identifier.issn2073-4409pt
dc.identifier.urihttps://hdl.handle.net/10316/112590-
dc.description.abstractAmyotrophic lateral sclerosis (ALS) is a severe and incurable neurodegenerative disease characterized by the progressive death of motor neurons, leading to paralysis and death. It is a rare disease characterized by high patient-to-patient heterogeneity, which makes its study arduous and complex. Extracellular vesicles (EVs) have emerged as important players in the development of ALS. Thus, ALS phenotype-expressing cells can spread their abnormal bioactive cargo through the secretion of EVs, even in distant tissues. Importantly, owing to their nature and composition, EVs' formation and cargo can be exploited for better comprehension of this elusive disease and identification of novel biomarkers, as well as for potential therapeutic applications, such as those based on stem cell-derived exosomes. This review highlights recent advances in the identification of the role of EVs in ALS etiopathology and how EVs can be promising new therapeutic strategies.pt
dc.language.isoengpt
dc.publisherMDPIpt
dc.relationThis work was financed by the European Regional Development Fund (ERDF) through the Centro 2020 Regional Operational Programme and through the COMPETE 2020—Operational Programme for Competitiveness and Internationalisation and Portuguese national funds via FCT— Fundação para a Ciência e a Tecnologia, under projects PTDC/BTM-ORG/0055/2021, UIDB/04539/ 2020, UIDP/04539/2020, and LA/P/0058/2020. CC was supported by FCT (Ref: 2022.13281.BD). S.I.M. was supported by FCT (Ref: DL57/2016/CP1448/CT0027). G.J.M.A. was supported by FCT under a fellowship from project PTDC/BTM-ORG/0055/2021. E.F. was supported by FCT under CEECIND/00322/2017 and 2022.00011.CEECIND.pt
dc.rightsopenAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt
dc.subjectamyotrophic lateral sclerosispt
dc.subjectneurodegenerative diseasespt
dc.subjectextracellular vesiclespt
dc.subjectexosomespt
dc.subjectmiRNApt
dc.subjectbiomarkerspt
dc.subject.meshHumanspt
dc.subject.meshMotor Neuronspt
dc.subject.meshAmyotrophic Lateral Sclerosispt
dc.subject.meshNeurodegenerative Diseasespt
dc.subject.meshExtracellular Vesiclespt
dc.subject.meshExosomespt
dc.titleRecent Advances in Extracellular Vesicles in Amyotrophic Lateral Sclerosis and Emergent Perspectivespt
dc.typearticle-
degois.publication.firstPage1763pt
degois.publication.issue13pt
degois.publication.titleCellspt
dc.peerreviewedyespt
dc.identifier.doi10.3390/cells12131763pt
degois.publication.volume12pt
dc.date.embargo2023-07-01*
uc.date.periodoEmbargo0pt
item.grantfulltextopen-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.openairetypearticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextCom Texto completo-
crisitem.author.researchunitCIBIT - Coimbra Institute for Biomedical Imaging and Translational Research-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.orcid0000-0001-9623-5012-
crisitem.author.orcid0000-0002-1200-4602-
Appears in Collections:IIIUC - Artigos em Revistas Internacionais
I&D CIBB - Artigos em Revistas Internacionais
I&D CNC - Artigos em Revistas Internacionais
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