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Título: | Coamorphous Systems of Valsartan: Thermal Analysis Contribution to Evaluate Intermolecular Interactions Effects on the Structural Relaxation | Autor: | Ekawa, Bruno Diogo, Hermínio P Castro, Ricardo A. E. Caires, Flávio J Eusébio, M. Ermelinda S. |
Palavras-chave: | valsartan; coamorphous; glass transition; isoconversional kinetic; TSDC | Data: | 25-Ago-2023 | Editora: | MDPI | Projeto: | This research was funded by FAPESP (Grant no. 2018/24378-6), CNPq (Grant nos. 422893/2021-8 and 317282/2021-2), CAPES PrInt (Grant no. 88887.582123/2020-00), and FCT, Portugal, Project UID/QUI/00313/2020. Part of this work was supported by FCT, Portugal, Projects UIDB/00100/2020, UIDP/00100/2020, and IMS-LA/P/0056/2020UIDB/00100/2020. | Título da revista, periódico, livro ou evento: | Molecules | Volume: | 28 | Número: | 17 | Resumo: | Coamorphous formation in binary systems of valsartan (Val) with 4,4'-bipyridine (Bipy) and trimethoprim (Tri) was investigated for mixtures with a mole fraction of 0.16~0.86 of valsartan and evaluated in terms of the glass transition temperature. The glass transition of the systems had a behavior outside the values predicted by the Gordon-Taylor equation, showing that Val-Bipy (hydrogen bonding between the components) had a lower deviation and Val-Tri (ionic bonding between the components) had a higher deviation. Mixtures of compositions 2:1 Val-Bipy and 1:1 Val-Tri were selected for further investigation and verified to be stable, as no crystallization was observed during subsequent heating and cooling programs. For these systems, the effective activation energy during glass transition was evaluated. Compared to pure valsartan, the system with the lower glass transition temperature (Val-Bipy) presented the highest effective activation energy, and the system with the higher glass transition temperature (Val-Tri) presented a lower effective activation energy. The results presented a good correlation between the data obtained from two different techniques to determine the fragility and effective activation energy: non-isothermal kinetic analysis by DSC and TSDC. | URI: | https://hdl.handle.net/10316/111919 | ISSN: | 1420-3049 | DOI: | 10.3390/molecules28176240 | Direitos: | openAccess |
Aparece nas coleções: | FCTUC Química - Artigos em Revistas Internacionais I&D CQC - Artigos em Revistas Internacionais |
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Coamorphous-Systems-of-Valsartan-Thermal-Analysis-Contribution-to-Evaluate-Intermolecular-Interactions-Effects-on-the-Structural-RelaxationMolecules.pdf | 2.92 MB | Adobe PDF | Ver/Abrir |
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