Utilize este identificador para referenciar este registo: https://hdl.handle.net/10316/111757
Título: Is hybrid therapy more efficient in the eradication of Helicobacter pylori infection? A systematic review and meta-analysis
Autor: Temido, Maria José 
Mbanze, Dara
Almeida, Nuno 
Oliveiros, Bárbara 
Gravito-Soares, Elisa 
Figueiredo, Pedro 
Palavras-chave: Helicobacter pylori; Hybrid therapy; Sequential therapy; Concomitant therapy; Meta-analysis
Data: 4-Jul-2023
Editora: Springer Nature
Título da revista, periódico, livro ou evento: Annals of Clinical Microbiology and Antimicrobials
Volume: 22
Número: 1
Resumo: Introduction Hybrid therapy (HT) is a non-bismuth quadruple therapy created to surpass Helicobacter pylori’s (H. pylori) resistance rates to antibiotics. HT has excellent eradication rates, as well as a very good compliance and safety profile. We aim to compare HT with sequential therapy (ST) and concomitant therapy (CT) for the eradication of H. pylori. Methods This systematic review was conducted following the principles of the PRISMA guidelines. Literature was electronically searched on the CENTRAL library, PubMed, Embase, Scopus, LILACS, and ClinicalTrials.gov. Only randomized controlled trials were included. The primary outcome evaluated was eradication rate of H. pylori. The secondary outcomes evaluated were adverse events and compliance rates. Meta-analyses were performed with Cochrane Review Manager 5.4. The Mantel–Haenszel method was used to estimate the pooled relative risk and 95% confidence interval of the eradication rates between HT and other regimens, as well as the secondary outcomes. Results 10 studies were included, comprising 2993 patients. The mean eradication rates achieved by HT with intention-to-treat (ITT) and per-protocol (PP) analyses were, respectively, 86% (range: 79.2–90.8%) and 91.7% (range: 82.6–96.1%). No statistically significant difference was found in ITT eradication rate between HT and CT (relative risk: 1; 95% CI: 0.96- 1.03) and between HT and ST (relative risk: 1.02; 95% CI: 0.92–1.14). PP analysis revealed similar results. HT was associated with higher compliance rates than CT and slightly lower than ST. As far as adverse events are concerned, this meta-analysis demonstrated a higher occurrence of adverse events on the group of patients treated with CT when compared with HT. HT and ST showed similar results. Conclusion HT has similar eradication, compliance and adverse event rates when compared to ST, but a better safety profile than the CT.
URI: https://hdl.handle.net/10316/111757
ISSN: 1476-0711
DOI: 10.1186/s12941-023-00582-2
Direitos: openAccess
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