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https://hdl.handle.net/10316/109931
Title: | Highly dynamic host actin reorganization around developing Plasmodium inside hepatocytes | Authors: | Gomes-Santos, Carina S. S. Itoe, Maurice A. Afonso, Cristina Henriques, Ricardo Gardner, Rui Sepúlveda, Nuno Simões, Pedro D. Raquel, Helena Almeida, António Paulo Moita, Luis F. Frischknecht, Friedrich Mota, Maria M. |
Issue Date: | 2012 | Publisher: | Public Library of Science | Project: | PTDC/SAU-GMG/100313/2008 SFRH/BD/15888/2005 PTDC/SAU-MII/69280/2006 PTDC/SAU-MII/78333/2006 |
Serial title, monograph or event: | PLoS ONE | Volume: | 7 | Issue: | 1 | Abstract: | Plasmodium sporozoites are transmitted by Anopheles mosquitoes and infect hepatocytes, where a single sporozoite replicates into thousands of merozoites inside a parasitophorous vacuole. The nature of the Plasmodium-host cell interface, as well as the interactions occurring between these two organisms, remains largely unknown. Here we show that highly dynamic hepatocyte actin reorganization events occur around developing Plasmodium berghei parasites inside human hepatoma cells. Actin reorganization is most prominent between 10 to 16 hours post infection and depends on the actin severing and capping protein, gelsolin. Live cell imaging studies also suggest that the hepatocyte cytoskeleton may contribute to parasite elimination during Plasmodium development in the liver. | URI: | http://hdl.handle.net/10316/109931 | ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0029408 | Rights: | openAccess |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais |
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Highly-dynamic-host-actin-reorganization-around-developing-Plasmodium-inside-hepatocytesPLoS-ONE.pdf | 1.98 MB | Adobe PDF | View/Open |
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