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https://hdl.handle.net/10316/109902
Título: | Revisiting thyroid hormones in schizophrenia | Autor: | Santos, Nadine Correia Costa, Patrício Ruano, Dina Macedo, António Soares, Maria João Valente, José Pereira, Ana Telma Azevedo, Maria Helena Palha, Joana Almeida |
Data: | 2012 | Editora: | Hindawi | Projeto: | Grant POCI/SAUESP/ 58757/2004 from the Portuguese Science Foundation (FCT/FEDER) FCT - SFRH/ BPD/51057/2010 |
Título da revista, periódico, livro ou evento: | Journal of Thyroid Research | Volume: | 2012 | Resumo: | Thyroid hormones are crucial during development and in the adult brain. Of interest, fluctuations in the levels of thyroid hormones at various times during development and throughout life can impact on psychiatric disease manifestation and response to treatment. Here we review research on thyroid function assessment in schizophrenia, relating interrelations between the pituitary-thyroid axis and major neurosignaling systems involved in schizophrenia's pathophysiology. These include the serotonergic, dopaminergic, glutamatergic, and GABAergic networks, as well as myelination and inflammatory processes. The available evidence supports that thyroid hormones deregulation is a common feature in schizophrenia and that the implications of thyroid hormones homeostasis in the fine-tuning of crucial brain networks warrants further research. | URI: | http://hdl.handle.net/10316/109902 | ISSN: | 2090-8067 2042-0072 |
DOI: | 10.1155/2012/569147 | Direitos: | openAccess |
Aparece nas coleções: | FMUC Medicina - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Revisiting-thyroid-hormones-in-schizophreniaJournal-of-Thyroid-Research.pdf | 1.27 MB | Adobe PDF | Ver/Abrir |
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