Utilize este identificador para referenciar este registo: https://hdl.handle.net/10316/109872
Título: Glycogen synthase kinase 3: a point of integration in Alzheimer's disease and a therapeutic target?
Autor: Mondragón-Rodríguez, Siddhartha
Perry, George
Zhu, Xiongwei 
Moreira, Paula I. 
Williams, Sylvain
Data: 2012
Editora: Hindawi
Projeto: National Center for Research Resources (5 G12RR013646-12), 
National Institute on Minority Health and Health Disparities (G12MD007591) from theNational Institutes ofHealth 
Research Centers in Minority Institutions (RCMI) 
Título da revista, periódico, livro ou evento: International Journal of Alzheimer's Disease
Volume: 2012
Resumo: Glycogen synthase kinase 3 (GSK3) has been implicated in neurological disorders; therefore, it is not surprising that there has been an increased focus towards developing therapies directed to this kinase. Unfortunately, these current therapies have not taken into consideration the physiological role of GSK3 in crucial events like synaptic plasticity. With this in mind we will discuss the relationship of synaptic plasticity with GSK3 and tau protein and their role as potential targets for the development of therapeutic strategies. Finally, we will provide perspectives in developing a cocktail therapy for Alzheimer's treatment.
URI: http://hdl.handle.net/10316/109872
ISSN: 2090-8024
2090-0252
DOI: 10.1155/2012/276803
Direitos: openAccess
Aparece nas coleções:FMUC Medicina - Artigos em Revistas Internacionais
I&D CNC - Artigos em Revistas Internacionais

Mostrar registo em formato completo

Visualizações de página

28
Visto em 8/mai/2024

Downloads

1
Visto em 8/mai/2024

Google ScholarTM

Verificar

Altmetric

Altmetric


Este registo está protegido por Licença Creative Commons Creative Commons