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https://hdl.handle.net/10316/109872| Title: | Glycogen synthase kinase 3: a point of integration in Alzheimer's disease and a therapeutic target? | Authors: | Mondragón-Rodríguez, Siddhartha Perry, George Zhu, Xiongwei Moreira, Paula I. Williams, Sylvain |
Issue Date: | 2012 | Publisher: | Hindawi | Project: | National Center for Research Resources (5 G12RR013646-12), National Institute on Minority Health and Health Disparities (G12MD007591) from theNational Institutes ofHealth Research Centers in Minority Institutions (RCMI) |
Serial title, monograph or event: | International Journal of Alzheimer's Disease | Volume: | 2012 | Abstract: | Glycogen synthase kinase 3 (GSK3) has been implicated in neurological disorders; therefore, it is not surprising that there has been an increased focus towards developing therapies directed to this kinase. Unfortunately, these current therapies have not taken into consideration the physiological role of GSK3 in crucial events like synaptic plasticity. With this in mind we will discuss the relationship of synaptic plasticity with GSK3 and tau protein and their role as potential targets for the development of therapeutic strategies. Finally, we will provide perspectives in developing a cocktail therapy for Alzheimer's treatment. | URI: | http://hdl.handle.net/10316/109872 | ISSN: | 2090-8024 2090-0252 |
DOI: | 10.1155/2012/276803 | Rights: | openAccess |
| Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais |
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|---|---|---|---|---|
| Glycogen-synthase-kinase-3-A-point-of-integration-in-alzheimers-disease-and-a-therapeutic-targetInternational-Journal-of-Alzheimers-Disease.pdf | 1.22 MB | Adobe PDF | View/Open |
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