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https://hdl.handle.net/10316/109741
Título: | Control of uterine microenvironment by foxp3(+) cells facilitates embryo implantation | Autor: | Teles, Ana Schumacher, Ann Kühnle, Marie-Cristine Linzke, Nadja Thuere, Catharina Reichardt, Peter Tadokoro, Carlos Eduardo Hämmerling, Günter J Zenclussen, Ana Claudia |
Palavras-chave: | regulatoryT cells; implantation; pregnancy; fibrosis; inflammation | Data: | 2013 | Editora: | Frontiers Media S.A. | Projeto: | Thisworkwassupportedby DFG grantstoAnaClaudiaZenclussen(ZE526/4-2andSFB854 TP7), andbygrantsfromtheWilhelmSanderStiftungGermany (grant2009.022.1)andHelmholtzAllianceforImmunotherapy toGünterJ.Hämmerling.AnaTeleswassupportedbytheFCT Foundation,PortugalandaPhDgrantfromtheMedicalFaculty, Otto-von-GuerickeUniversity,Magdeburg. | Título da revista, periódico, livro ou evento: | Frontiers in Immunology | Volume: | 4 | Número: | JUN | Resumo: | Implantation of the fertilized egg into the maternal uterus depends on the fine balance between inflammatory and anti-inflammatory processes. Whilst regulatory T cells (Tregs) are reportedly involved in protection of allogeneic fetuses against rejection by the maternal immune system, their role for pregnancy to establish, e.g., blastocyst implantation, is not clear. By using 2-photon imaging we show that Foxp3(+) cells accumulated in the mouse uterus during the receptive phase of the estrus cycle. Seminal fluid further fostered Treg expansion. Depletion of Tregs in two Foxp3.DTR-based models prior to pairing drastically impaired implantation and resulted in infiltration of activated T effector cells as well as in uterine inflammation and fibrosis in both allogeneic and syngeneic mating combinations. Genetic deletion of the homing receptor CCR7 interfered with accumulation of Tregs in the uterus and implantation indicating that homing of Tregs to the uterus was mediated by CCR7. Our results demonstrate that Tregs play a critical role in embryo implantation by preventing the development of a hostile uterine microenvironment. | URI: | https://hdl.handle.net/10316/109741 | ISSN: | 1664-3224 | DOI: | 10.3389/fimmu.2013.00158 | Direitos: | openAccess |
Aparece nas coleções: | I&D CNC - Artigos em Revistas Internacionais |
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Control of uterine microenvironment by Foxp3+ cells facilitates embryo implantation.pdf | 2.63 MB | Adobe PDF | Ver/Abrir |
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