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https://hdl.handle.net/10316/109731
Title: | Markers of increased cardiovascular risk in postmenopausal women: focus on oxidized-LDL and HDL subpopulations | Authors: | Mascarenhas-Melo, Filipa Sereno, José Lemos, Edite Teixeira de Ribeiro, Sandra Rocha-Pereira, Petronila Cotterill, Ethan Teixeira, Frederico Reis, Flávio |
Issue Date: | 2013 | Publisher: | Hindawi | Project: | SFRH/BD/ 65483/2009 PEst-C/SAU/UI3282/ 2011 COMPETE |
Serial title, monograph or event: | Disease Markers | Volume: | 35 | Issue: | 2 | Abstract: | To evaluate the effect of gender and menopause in cardiovascular risk (CVR) in a healthy population based on both classical and nontraditional markers. Methods. 56 men and 68 women (48 pre- and 20 postmenopause) were enrolled in the study. The following markers were analyzed: blood pressure (BP), body mass index (BMI), waist circumference (WC), glucose, total cholesterol (total-c), triglycerides (TGs), low-density lipoprotein cholesterol (LDL-c), oxidized-LDL (Ox-LDL), HDL-c and subpopulations, paraoxonase-1 activity, hsCRP, uric acid, tumor necrosis factor alpha (TNF-𝛼), adiponectin, vascular endothelial growth factor (VEGF), and intercellular adhesion molecular 1 (ICAM1). Results. Relative to the women, men present significantly increased BMI,WC, BP, glucose, total-c, TGs, LDL-c, Ox-LDL, uric acid, and TNF-𝛼 and reduced adiponectin and total and large HDL-c. The protective profile of women is lost after menopause with a significantly increased BMI, WC, BP, glucose, LDL-c, Ox- LDL, hsCRP, and VEGF and decreased total and large HDL-c. Significant correlations were found in women population and in postmenopausal women between Ox-LDL and total, large, and small HDL-c and between TNF-𝛼 and total, large, and small HDLc, LDL-c, and Ox-LDL. Conclusions. Men present higher CVR than women who lost protection after menopause, evidenced by nontraditional markers, including Ox-LDL and HDL subpopulations. | URI: | https://hdl.handle.net/10316/109731 | ISSN: | 0278-0240 1875-8630 |
DOI: | 10.1155/2013/724706 | Rights: | openAccess |
Appears in Collections: | FCTUC Matemática - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais |
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Markers-of-increased-cardiovascular-risk-in-postmenopausal-women-Focus-on-oxidizedLDL-and-HDL-subpopulationsDisease-Markers.pdf | 5.44 MB | Adobe PDF | View/Open |
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