Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/109720
DC FieldValueLanguage
dc.contributor.authorRoque, Fátima-
dc.contributor.authorRama, Ana Cristina-
dc.contributor.authorSousa, João-
dc.contributor.authorPina, Maria Eugénia-
dc.date.accessioned2023-10-24T09:58:01Z-
dc.date.available2023-10-24T09:58:01Z-
dc.date.issued2013-
dc.identifier.issn1984-8250pt
dc.identifier.urihttps://hdl.handle.net/10316/109720-
dc.description.abstractThe purpose of this study is to develop and improve oral liquids formulations of sildenafil citrate for paediatric use. Four different formulations were developed, which are as follows: two aqueous solutions of sildenafil citrate (2.5 mg/mL), with or without preservatives, and two other solutions of sildenafil in simple syrup (1.25 mg/mL), with or without preservatives. All of the formulations were physically, chemically and microbiologically stable for three months. The results of the stability studies allowed for the optimisation of formulations without preservatives due to their simplicity and their similar stable conditions when compared to the formulations containing antimicrobials. The shelf life of both formulations was three months; however, upon opening, aqueous solutions should be used within 10 days and kept refrigerated, and syrup solutions should be used within 14 days in a hospital setting.pt
dc.description.abstractO objetivo deste trabalho é desenvolver e otimizar formulações líquidas orais de citrato de sildenafil adequadas ao uso pediátrico. Foram desenvolvidas quatro formulações diferentes: duas soluções aquosas de citrato de sildenafila (2,5 mg/mL) com ou sem conservantes e duas soluções de citrato de sildenafil em xarope simples (1,25 mg/mL) com ou sem conservantes. Todas as formulações desenvolvidas apresentaram estabilidade quer físico-química quer microbiológica durante 3 meses. Os resultados dos estudos de estabilidade permitiram otimizar as formulações isentas de conservantes, uma vez que estas eram mais simples e apresentavam do mesmo modo uma boa estabilidade, comparando com as formulações que continham conservantes. O período de utilização de ambas as formulações é de três meses, no entanto, após abertura do frasco, a solução aquosa deve ser utilizada durante 10 dias, acondicionada no refrigerador e o xarope deve ser utilizado durante 14 dias, mesmo em ambiente hospitalar.pt
dc.language.isoengpt
dc.publisherUniversidade de Sao Paulopt
dc.rightsopenAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt
dc.subjectChemical stabilitypt
dc.subjectMicrobiological stabilitypt
dc.subjectSildenafil citratept
dc.subjectPaediatric formulationspt
dc.subjectEstabilidade químicapt
dc.subjectEstabilidade microbiológicapt
dc.subjectCitrato de sildenafilpt
dc.subjectFormulações pediátricaspt
dc.titleDevelopment and stability assessment of liquid paediatric formulations containing sildenafil citratept
dc.typearticle-
degois.publication.firstPage381pt
degois.publication.lastPage388pt
degois.publication.issue2pt
degois.publication.titleBrazilian Journal of Pharmaceutical Sciencespt
dc.peerreviewedyespt
dc.identifier.doi10.1590/S1984-82502013000200021pt
degois.publication.volume49pt
dc.date.embargo2013-01-01*
uc.date.periodoEmbargo0pt
item.cerifentitytypePublications-
item.languageiso639-1en-
item.fulltextCom Texto completo-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypearticle-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.researchunitCIEPQPF – Chemical Process Engineering and Forest Products Research Centre-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.orcid0000-0001-9718-8035-
crisitem.author.orcid0000-0003-0189-1370-
Appears in Collections:FFUC- Artigos em Revistas Internacionais
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