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Title: Oral and gastric Helicobacter pylori: effects and associations
Authors: Veiga, Nélio J. 
Pereira, Carlos
Resende, Carlos
Amaral, Odete
Ferreira, Manuela
Nelas, Paula
Chaves, Claudia
Duarte, João
Cirnes, Luís 
Machado, José Carlos 
Ferreira, Paula C. 
Correia, Ilídio J. 
Issue Date: 2015
Publisher: Public Library of Science
Project: Fundação para a Ciência e Tecnologia and CI&DETS (Portugal) 
Serial title, monograph or event: PLoS ONE
Volume: 10
Issue: 5
Abstract: This study consisted in the comparison of the prevalence of Helicobacter pylori (H. pylori) present in the stomach and in saliva of a sample of Portuguese adolescents and the assessment of the association between H. pylori infection with socio-demographic variables and prevalence of dental caries. Materials and Methods A cross-sectional study was designed including a sample of 447 adolescents aged 12 to 19 years old, attending a public school in Sátão, Portugal. A questionnaire about socio-demographic variables and oral health behaviors was applied. Gastric H. pylori infection was determined using the urease breath test (UBT). Saliva collection was obtained and DNA was extracted by Polymerase Chain Reaction (PCR) in order to detect the presence of oral H. pylori. Results The prevalence of gastric H. pylori detected by UBT was 35.9%. Within the adolescents with a gastric UBT positive, only 1.9% were positive for oral H. pylori. The presence of gastric H. pylori was found to be associated with age (>15years, Odds ratio(OR)=1.64,95% CI=1.08-2.52), residence area (urban,OR=1.48,95%CI=1.03-2.29) and parents´ professional situation (unemployed,OR=1.22,95%CI=1.02-1.23). Among those with detected dental caries during the intra-oral observation, 37.4% were positive for gastric H. pylori and 40.2% negative for the same bacterial strain (p=0.3). Conclusions The oral cavity cannot be considered a reservoir for infection of H. pylori. Gastric H. pylori infection was found to be associated with socio-demographic variables such as age, residence area and socioeconomic status.
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0126923
Rights: openAccess
Appears in Collections:I&D CIEPQPF - Artigos em Revistas Internacionais

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