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Title: | Elevated Glucose and Interleukin-1β Differentially Affect Retinal Microglial Cell Proliferation | Authors: | Baptista, Filipa I. Aveleira, Célia A. Castilho, Áurea F. Ambrósio, António F. |
Issue Date: | 2017 | Publisher: | Hindawi | Project: | SFRH/BPD/86830/2012 SFR H/BD/35961/2007 SFRH/BD/30235/2006 SFRH/BPD/111 710/2015 SFRH/BPD/73942/2010 SFRH/BD/18827/2004 UID/ NEU/04539/2013 POCI-01-0145-FEDER-007440 CENTRO- 01-0145-FEDER-000008 |
Serial title, monograph or event: | Mediators of Inflammation | Volume: | 2017 | Abstract: | Diabetic retinopathy is considered a neurovascular disorder, hyperglycemia being considered the main risk factor for this pathology. Diabetic retinopathy also presents features of a low-grade chronic inflammatory disease, including increased levels of cytokines in the retina, such as interleukin-1 beta (IL-1β). However, how high glucose and IL-1β affect the different retinal cell types remains to be clarified. In retinal neural cell cultures, we found that IL-1β and IL-1RI are present in microglia, macroglia, and neurons. Exposure of retinal neural cell cultures to high glucose upregulated both mRNA and protein levels of IL-1β. High glucose decreased microglial and macroglial cell proliferation, whereas IL-1β increased their proliferation. Interestingly, under high glucose condition, although the number of microglial cells decreased, they showed a less ramified morphology, suggesting a more activated state, as supported by the upregulation of the levels of ED-1, a marker of microglia activation. In conclusion, IL-1β might play a key role in diabetic retinopathy, affecting microglial and macroglial cells and ultimately contributing to neural changes observed in diabetic patients. Particularly, since IL-1β has an important role in retinal microglia activation and proliferation under diabetes, limiting IL-1β-triggered inflammatory processes may provide a new therapeutic strategy to prevent the progression of diabetic retinopathy. | URI: | https://hdl.handle.net/10316/108269 | ISSN: | 0962-9351 1466-1861 |
DOI: | 10.1155/2017/4316316 | Rights: | openAccess |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais I&D IBILI - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais |
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