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Title: Renoprotective Effects of the Dipeptidyl Peptidase-4 Inhibitor Sitagliptin: A Review in Type 2 Diabetes
Authors: Mega, Cristina
Teixeira-de-Lemos, Edite
Fernandes, Rosa 
Reis, Flávio 
Issue Date: 2017
Publisher: Hindawi
Project: PEst-C/SAU/UI3282/2013 
CNC.IBILI Strategic Project (2015-UID/NEU/04539/2013) 
POCI-01-0145-FEDER- 007440 
(CENTRO-01-0145-FEDER-000012: Healthy- Aging2020 and CENTRO-01-0145-FEDER-000008: Brain- Health 2020) 
PROTEC grant by the Polytechnic Institute of Viseu (IPV) (PROTEC-SFRH/ BD/50139/2009) 
Serial title, monograph or event: Journal of Diabetes Research
Volume: 2017
Abstract: Diabetic nephropathy (DN) is now the single commonest cause of end-stage renal disease (ESRD) worldwide and one of the main causes of death in diabetic patients. It is also acknowledged as an independent risk factor for cardiovascular disease (CVD). Since sitagliptin was approved, many studies have been carried out revealing its ability to not only improve metabolic control but also ameliorate dysfunction in various diabetes-targeted organs, especially the kidney, due to putative underlying cytoprotective properties, namely, its antiapoptotic, antioxidant, anti-inflammatory, and antifibrotic properties. Despite overall recommendations, many patients spend a long time well outside the recommended glycaemic range and, therefore, have an increased risk for developing micro- and macrovascular complications. Currently, it is becoming clearer that type 2 diabetes mellitus (T2DM) management must envision not only the improvement in glycaemic control but also, and particularly, the prevention of pancreatic deterioration and the evolution of complications, such as DN. This review aims to provide an overview of the current knowledge in the field of renoprotective actions of sitagliptin, namely, improvement in diabetic dysmetabolism, hemodynamic factors, renal function, diabetic kidney lesions, and cytoprotective properties.
ISSN: 2314-6745
DOI: 10.1155/2017/5164292
Rights: openAccess
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais
I&D IBILI - Artigos em Revistas Internacionais
FMUC Medicina - Artigos em Revistas Internacionais

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