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Title: Coriolus versicolor biomass increases dendritic arborization of newly-generated neurons in mouse hippocampal dentate gyrus
Authors: Ferreiro, Elisabete 
Pita, Inês R. 
Mota, Sandra 
Valero, Jorge 
Ferreira, Nuno R. 
Fernandes, Tito
Calabrese, Vittorio
Fontes-Ribeiro, Carlos A. 
Pereira, Frederico C. 
Rego, Ana Cristina 
Keywords: coriolus versicolor; cognitive reserve; hippocampus; neurogenesis; immature neuron complexity
Issue Date: 31-Aug-2018
Publisher: Impact Journals
Project: This work was supported by Mycology Research Laboratories, Ltd. This work was financed by the European Regional Development Fund (ERDF), through the Centro 2020 Regional Operational Programme under projects CENTRO-01-0145-FEDER-000012-HealthyAging2020 and CENTRO-01-0145-FEDER-000008 - BrainHealth 2020, and through the COMPETE 2020 - Operational Programme for Competitiveness and Internationalisation and Portuguese national funds via FCT – Fundação para a Ciência e a Tecnologia, under project POCI-01- 0145-FEDER-007440 and Strategic Project 2015- UID/ NEU/04539/2013. EF and SIM are holders of FCT postdoctoral grant (SFRH/BPD/86551/2012 and SFRH/ BPD/99219/2013, respectively). J.V. salary was supported by an Ikerbasque Research Fellow grant. 
Serial title, monograph or event: Oncotarget
Volume: 9
Issue: 68
Abstract: Brain cognitive reserve refers to the ability of the brain to manage different challenges that arise throughout life, making it resilient to neuropathology. Hippocampal adult neurogenesis has been considered to be a relevant contributor for brain cognitive reserve and brain plasticity. Coriolus versicolor (CV), a common healthful mushroom, has been receiving increasing attention by its antitumoral, anti-inflammatory, antioxidant, antibacterial, and immunomodulatory properties, including in the hippocampus. Herein, we evaluated whether CV biomass oral administration for 2.5 months enhances hippocampal neurogenic reserve under normal/physiological conditions, by quantifying hippocampal dentate gyrus (DG) granular cell layer (GCL) and subgranular zone (SGZ) volumes, proliferation, number and dendritic complexity features of hippocampal newly-generated neurons. We also analyzed β-catenin levels in DG newly-generated immature neurons, because it plays a major role in neurogenesis. Although no differences were observed in the volume of GCL and SGZ layers, in proliferation and in the number of newly-generated neurons of controls and CV-administered mice, we found that CV administration promotes a significant increase in dendritic length and branching and total dendritic volume of immature neurons, suggesting a positive effect of oral CV administration in the hippocampal neurogenic reserve. We also observed that β-catenin levels are increased both in the nucleus and cytoplasm of DG immature neurons, suggesting that Wnt/β-catenin signalling may play an important role in the CV positive effect on the differentiation of these cells. These data unveil a so far unexplored neurogenic potential of CV supplementation, which emerges as a possible preventive strategy for different neurological conditions.
ISSN: 1949-2553
DOI: 10.18632/oncotarget.25978
Rights: openAccess
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais
IIIUC - Artigos em Revistas Internacionais
FMUC Medicina - Artigos em Revistas Internacionais
FFUC- Artigos em Revistas Internacionais
I&D IBILI - Artigos em Revistas Internacionais

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