This work was supported by Mycology Research Laboratories, Ltd. This work was financed by the European Regional Development Fund (ERDF), through the Centro 2020 Regional Operational Programme under projects CENTRO-01-0145-FEDER-000012-HealthyAging2020 and CENTRO-01-0145-FEDER-000008 - BrainHealth 2020, and through the COMPETE 2020 - Operational Programme for Competitiveness and Internationalisation and Portuguese national funds via FCT – Fundação para a Ciência e a Tecnologia, under project POCI-01- 0145-FEDER-007440 and Strategic Project 2015- UID/ NEU/04539/2013. EF and SIM are holders of FCT postdoctoral grant (SFRH/BPD/86551/2012 and SFRH/ BPD/99219/2013, respectively). J.V. salary was supported by an Ikerbasque Research Fellow grant.