Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/107767
Title: Doping β-TCP as a Strategy for Enhancing the Regenerative Potential of Composite β-TCP-Alkali-Free Bioactive Glass Bone Grafts. Experimental Study in Rats
Authors: Ferreira, Manuel M. 
Brito, Ana F. 
Brazete, Daniela
Pereira, Inês C.
Carrilho, Eunice 
Abrantes, Ana M. 
Pires, Ana S. 
Aguiar, Maria J
Carvalho, Lina 
Botelho, Filomena 
Ferreira, José M. F.
Keywords: composite bone grafts; calcium phosphates; implants; dentistry; biomedical engineering; osteogenesis
Issue Date: 20-Dec-2018
Publisher: MDPI
Project: UID/CTM/50011/2013 
PEst-UID/NEU/04539/2013 
FCOMP-01-0124-FEDER-028417 
POCI-01-0145-FEDER-007440 
Serial title, monograph or event: Materials
Volume: 12
Issue: 1
Abstract: The present work aims at evaluating the potential gains derived from partially replacing calcium in resorbable β-tricalcium phosphate (β-TCP) by two different molar percentages of strontium (5, 10) and zinc (1, 2), concomitantly with a fixed molar percentage (0.5) of manganese. Synthetic granular composite bone filling grafts consisting of doped β-TCP and an alkali-free bioactive glass were prepared and implanted in ~4 mm diameter bone defects drilled in the calvaria of Wistar rats used as animal models. The animals were sacrificed after 9 weeks of implantation and the calvaria was excised. Non-manipulated bone was used as positive control, while empty defects were used as a negative control group. The von Kossa staining revealed an enhanced new bone formation with increasing doping levels, supporting the therapeutic effects exerted by the doping elements. The percentage of newly formed bone was similar when the defects were filled with autologous bone, BG (previous results) or 3TCP2/7BG, which indicates that the latter two are excellent candidates for replacement of autologous bone as bone regeneration material. This finding confirms that doping with suitable doses of therapeutic ions is a good strategy towards transposing the bone graft materials to biomedical applications in humans.
URI: https://hdl.handle.net/10316/107767
ISSN: 1996-1944
DOI: 10.3390/ma12010004
Rights: openAccess
Appears in Collections:I&D IBILI - Artigos em Revistas Internacionais
FMUC Medicina - Artigos em Revistas Internacionais
I&D ICBR - Artigos em Revistas Internacionais

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