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Título: | Bridging a Gap between Cr(VI)-Induced Oxidative Stress and Genotoxicity in Lettuce Organs after a Long-Term Exposure | Autor: | Monteiro, Cristina Sario, Sara Mendes, Rafael Mariz-Ponte, Nuno Silva, Sónia Oliveira, Helena Bastos, Verónica Santos, Conceição Dias, Maria Celeste |
Data: | 2018 | Editora: | Hindawi | Projeto: | UID/BIA/04004/2013 UID/ QUI/00062/2013 POCI/01/0145/FEDER/007265 UID/ QUI/50006/2013 SFRH/BPD/ 100865/2014 SFRH/BPD/74299/2010 SFRH/BD/100865/2017 |
Título da revista, periódico, livro ou evento: | International Journal of Agronomy | Volume: | 2018 | Resumo: | Chromium(Cr) contamination in arable soils and irrigating water remains a priority, particularly due to the challenges posed to crop production and food safety. Long-term Cr(VI) effects remain less addressed than short-term ones, particularly regarding organspecific genotoxic profiles. Here we used the crop Lactuca sativa growing in a protected horticultural system and irrigated for 21 days with Cr(VI) (up to 200mg/L). Besides the oxidative stress, the genotoxicity was evaluated. Shoots and roots showed distinctive oxidative stress status and genotoxic effects, in a dose-dependent manner.While 50mg/L stimulated antioxidant activities and no major genotoxic effects were found, plants exposed to ≥150 showed an increase of oxidative disorders, together with cytostatic and DNA damage effects, and some mitotic impairment. Leaves showed less oxidative signs at 50mg/L, while at 150/200mg/L the antioxidant battery was stimulated. In Cr treated plants, the highest dose increased the DNA damage, reinforcing the idea that DNA breaks were related to mitotic disorders in higher doses. In conclusion, long-term exposure data show a highly responsive root, with a quadratic response meaning higher defenses at lower Cr doses, and higher oxidative and DNA damage and cytostatic effect at a higher dose. | URI: | https://hdl.handle.net/10316/107686 | ISSN: | 1687-8159 1687-8167 |
DOI: | 10.1155/2018/5738014 | Direitos: | openAccess |
Aparece nas coleções: | I&D CFE - Artigos em Revistas Internacionais |
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Bridging-a-gap-between-CrVIinduced-oxidative-stress-and-genotoxicity-in-lettuce-organs-after-a-longterm-exposureInternational-Journal-of-Agronomy.pdf | 1.69 MB | Adobe PDF | Ver/Abrir |
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