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Title: Bridging a Gap between Cr(VI)-Induced Oxidative Stress and Genotoxicity in Lettuce Organs after a Long-Term Exposure
Authors: Monteiro, Cristina
Sario, Sara
Mendes, Rafael 
Mariz-Ponte, Nuno
Silva, Sónia
Oliveira, Helena
Bastos, Verónica
Santos, Conceição
Dias, Maria Celeste 
Issue Date: 2018
Publisher: Hindawi
Project: UID/BIA/04004/2013 
UID/ QUI/00062/2013 
UID/ QUI/50006/2013 
SFRH/BPD/ 100865/2014 
Serial title, monograph or event: International Journal of Agronomy
Volume: 2018
Abstract: Chromium(Cr) contamination in arable soils and irrigating water remains a priority, particularly due to the challenges posed to crop production and food safety. Long-term Cr(VI) effects remain less addressed than short-term ones, particularly regarding organspecific genotoxic profiles. Here we used the crop Lactuca sativa growing in a protected horticultural system and irrigated for 21 days with Cr(VI) (up to 200mg/L). Besides the oxidative stress, the genotoxicity was evaluated. Shoots and roots showed distinctive oxidative stress status and genotoxic effects, in a dose-dependent manner.While 50mg/L stimulated antioxidant activities and no major genotoxic effects were found, plants exposed to ≥150 showed an increase of oxidative disorders, together with cytostatic and DNA damage effects, and some mitotic impairment. Leaves showed less oxidative signs at 50mg/L, while at 150/200mg/L the antioxidant battery was stimulated. In Cr treated plants, the highest dose increased the DNA damage, reinforcing the idea that DNA breaks were related to mitotic disorders in higher doses. In conclusion, long-term exposure data show a highly responsive root, with a quadratic response meaning higher defenses at lower Cr doses, and higher oxidative and DNA damage and cytostatic effect at a higher dose.
ISSN: 1687-8159
DOI: 10.1155/2018/5738014
Rights: openAccess
Appears in Collections:I&D CFE - Artigos em Revistas Internacionais

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