Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/107636
Title: | Vascular Oxidative Stress: Impact and Therapeutic Approaches | Authors: | Sena, Cristina M. Leandro, Adriana Azul, Lara Seiça, Raquel Perry, George |
Keywords: | oxidative stress; vasculature; reactive oxygen species; therapies; antioxidants | Issue Date: | 2018 | Publisher: | Frontiers Media S.A. | Project: | PTDC/BIM-MET/4447/2014 POCI-01-0145-FEDER-016784 |
Serial title, monograph or event: | Frontiers in Physiology | Volume: | 9 | Abstract: | Oxidative stress has been defined as an imbalance between oxidants and antioxidants and more recently as a disruption of redox signaling and control. It is generally accepted that oxidative stress can lead to cell and tissue injury having a fundamental role in vascular dysfunction. Physiologically, reactive oxygen species (ROS) control vascular function by modulating various redox-sensitive signaling pathways. In vascular disorders, oxidative stress instigates endothelial dysfunction and inflammation, affecting several cells in the vascular wall. Vascular ROS are derived from multiple sources herein discussed, which are prime targets for therapeutic development. This review focuses on oxidative stress in vascular physiopathology and highlights different strategies to inhibit ROS production. | URI: | https://hdl.handle.net/10316/107636 | ISSN: | 1664-042X | DOI: | 10.3389/fphys.2018.01668 | Rights: | openAccess |
Appears in Collections: | I&D ICBR - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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Vascular oxidative stress Impact and therapeutic approaches.pdf | 4.13 MB | Adobe PDF | View/Open |
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