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Título: | Adenosine A2A Receptors Control Glutamatergic Synaptic Plasticity in Fast Spiking Interneurons of the Prefrontal Cortex | Autor: | Kerkhofs, Amber Canas, Paula M. Timmerman, A. J. Heistek, Tim S. Real, Joana I. Xavier, Carolina Cunha, Rodrigo A. Mansvelder, Huibert D. Ferreira, Samira G. |
Palavras-chave: | A2A receptor; prefrontal cortex (PFC); synaptic plasticity; fast-spiking interneurons; adenosine; LTP and LTD; electrophysiology | Data: | 2018 | Editora: | Frontiers Media S.A. | Projeto: | Supported by Maratona da Saúde, Santa Casa da Misericórdia, GAI-FMUC and Banco Santander-Totta, NARSAD, Erasmus Mundus Joint Doctorate grant (ENC-Network) and ERDF, through Centro 2020 (project no. CENTRO-01-0145-FEDER- 000008:BrainHealth 2020), and through FCT (project nos. POCI- 01-0145-FEDER-007440 and PTDC/NEU-NMC/4154/2016) to RC. HM received funding for this work from the Netherlands Organization for Scientific Research (NWO; VICI grant), ERC StG “BrainSignals,” EU H2020 Framework Program (agreement no. 604102 “Human Brain Project”) and the EU 7th Framework Program (no. EU MSCA-ITN CognitionNet FP7-PEOPLE-2013- ITN 607508). | Título da revista, periódico, livro ou evento: | Frontiers in Pharmacology | Volume: | 9 | Número: | MAR | Resumo: | Adenosine A2A receptors (A2AR) are activated upon increased synaptic activity to assist in the implementation of long-term plastic changes at synapses. While it is reported that A2AR are involved in the control of prefrontal cortex (PFC)-dependent behavior such as working memory, reversal learning and effort-based decision making, it is not known whether A2AR control glutamatergic synapse plasticity within the medial PFC (mPFC). To elucidate that, we tested whether A2AR blockade affects long-term plasticity (LTP) of excitatory post-synaptic potentials in pyramidal neurons and fast spiking (FS) interneurons in layer 5 of the mPFC and of population spikes. Our results show that A2AR are enriched at mPFC synapses, where their blockade reversed the direction of plasticity at excitatory synapses onto layer 5 FS interneurons from LTP to long-term depression, while their blockade had no effect on the induction of LTP at excitatory synapses onto layer 5 pyramidal neurons. At the network level, extracellularly induced LTP of population spikes was reduced by A2AR blockade. The interneuron-specificity of A2AR in controlling glutamatergic synapse LTP may ensure that during periods of high synaptic activity, a proper excitation/inhibition balance is maintained within the mPFC. | URI: | https://hdl.handle.net/10316/107632 | ISSN: | 1663-9812 | DOI: | 10.3389/fphar.2018.00133 | Direitos: | openAccess |
Aparece nas coleções: | FMUC Medicina - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais |
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Adenosine A2A receptors control glutamatergic synaptic plasticity in fast spiking interneurons of the prefrontal cortex.pdf | 2.8 MB | Adobe PDF | Ver/Abrir |
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