Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/107504
Title: Strategies and methodologies for the construction of spiro-γ-lactams: an update
Authors: Alves, Américo J. S. 
Alves, Nuno G. 
Soares, Maria I. L. 
Pinho e Melo, Teresa M. V. D. 
Keywords: γ-lactams; spiro-γ-lactams; spiropyrrolinin-2-ones; spirocyclic compounds; spirocyclization
Issue Date: 2021
Publisher: Royal Society of Chemistry
Project: UIDB/00313/2020 
UIDP/QUI/00313/2020 
SFRH/BD/128910/2017 
PD/BD/135287/2017 
Serial title, monograph or event: Organic Chemistry Frontiers
Volume: 8
Issue: 13
Abstract: Spiro-γ-lactams (spiropyrrolinin-2-ones) are a class of spirocyclic compounds that are present in a wide range of synthetic bioactive and naturally occurring molecules. The increasing attention to spirocyclic lactams in drug discovery has been accompanied by a growing interest in these compounds from a synthetic point of view, namely as synthetic building blocks in organic chemistry, due to their inherent rigidity and complexity. Herein, an insight into the most relevant advances in the synthesis of the spiro-γ-lactam scaffold since 2015 is provided, addressing issues such as scope, efficiency, selectivity and mechanistic insights.
URI: https://hdl.handle.net/10316/107504
ISSN: 2052-4129
DOI: 10.1039/D0QO01564D
Rights: embargoedAccess
Appears in Collections:I&D CQC - Artigos em Revistas Internacionais

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