Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/107504
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Alves, Américo J. S. | - |
dc.contributor.author | Alves, Nuno G. | - |
dc.contributor.author | Soares, Maria I. L. | - |
dc.contributor.author | Pinho e Melo, Teresa M. V. D. | - |
dc.date.accessioned | 2023-07-17T10:57:59Z | - |
dc.date.available | 2023-07-17T10:57:59Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 2052-4129 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/107504 | - |
dc.description.abstract | Spiro-γ-lactams (spiropyrrolinin-2-ones) are a class of spirocyclic compounds that are present in a wide range of synthetic bioactive and naturally occurring molecules. The increasing attention to spirocyclic lactams in drug discovery has been accompanied by a growing interest in these compounds from a synthetic point of view, namely as synthetic building blocks in organic chemistry, due to their inherent rigidity and complexity. Herein, an insight into the most relevant advances in the synthesis of the spiro-γ-lactam scaffold since 2015 is provided, addressing issues such as scope, efficiency, selectivity and mechanistic insights. | pt |
dc.language.iso | eng | pt |
dc.publisher | Royal Society of Chemistry | pt |
dc.relation | UIDB/00313/2020 | pt |
dc.relation | UIDP/QUI/00313/2020 | pt |
dc.relation | SFRH/BD/128910/2017 | pt |
dc.relation | PD/BD/135287/2017 | pt |
dc.rights | embargoedAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | pt |
dc.subject | γ-lactams | pt |
dc.subject | spiro-γ-lactams | pt |
dc.subject | spiropyrrolinin-2-ones | pt |
dc.subject | spirocyclic compounds | pt |
dc.subject | spirocyclization | pt |
dc.title | Strategies and methodologies for the construction of spiro-γ-lactams: an update | pt |
dc.type | article | - |
degois.publication.firstPage | 3543 | pt |
degois.publication.lastPage | 3593 | pt |
degois.publication.issue | 13 | pt |
degois.publication.title | Organic Chemistry Frontiers | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1039/D0QO01564D | pt |
degois.publication.volume | 8 | pt |
dc.date.embargo | 2022-01-01 | * |
uc.date.periodoEmbargo | 365 | pt |
item.grantfulltext | open | - |
item.fulltext | Com Texto completo | - |
item.openairetype | article | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.orcid | 0000-0001-8860-0470 | - |
crisitem.author.orcid | 0000-0003-3256-4954 | - |
Appears in Collections: | I&D CQC - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Strategiesand methodologies for_Alves2021OrgChemFront.pdf | 7.22 MB | Adobe PDF | View/Open |
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