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Title: Applications of Photodynamic Therapy in Endometrial Diseases
Authors: Correia-Barros, Gabriela 
Serambeque, Beatriz 
Carvalho, Maria João 
Marto, Carlos Miguel 
Pineiro, Marta 
Pinho e Melo, Teresa M. V. D. 
Botelho, M. Filomena 
Laranjo, Mafalda 
Keywords: endometrial neoplasms; endometrium; models; animal; photochemotherapy; photodynamic therapy; therapeutics
Issue Date: 23-May-2022
Publisher: MDPI
Project: This research was funded by the Foundation for Science and Technology (FCT), Portugal, and the European Social Fund (FSE), through a PhD fellowship awarded to Beatriz Serambeque (2020.07672.BD). Project PTDC/QUI-QOR/0103/2021 was financed by FCT, I.P./MCTES, by national funds (PIDDAC). CIBB was supported by National Funds via FCT through the Strategic Projects UID/NEU/04539/2019, UIDB/04539/2020, UIDP/04539/2020, and by COMPETE-FEDER (POCI- 01-0145-FEDER-007440). Coimbra Chemistry Centre (CQC) was supported by FCT under projects UIDB/00313/2020 and UIDP/00313/2020. 
Serial title, monograph or event: Bioengineering
Volume: 9
Issue: 5
Abstract: Photodynamic therapy (PDT) is a medical procedure useful for several benign conditions (such as wound healing and infections) and cancer. PDT is minimally invasive, presents few side effects, good scaring, and is able to minimal tissue destruction maintaining organ anatomy and function. Endoscopic access to the uterus puts PDT in the spotlight for endometrial disease treatment. This work systematically reviews the current evidence of PDT's potential and usefulness in endometrial diseases. Thus, this narrative review focused on PDT applications for endometrial disease, including reports regarding in vitro, ex vivo, animal, and clinical studies. Cell lines and primary samples were used as in vitro models of cancer, adenomyosis and endometrioses, while most animal studies focused the PDT outcomes on endometrial ablation. A few clinical attempts are known using PDT for endometrial ablation and cancer lesions. This review emphasises PDT as a promising field of research. This therapeutic approach has the potential to become an effective conservative treatment method for endometrial benign and malignant lesions. Further investigations with improved photosensitisers are highly expected.
ISSN: 2306-5354
DOI: 10.3390/bioengineering9050226
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
I&D CIBB - Artigos em Revistas Internacionais
I&D ICBR - Artigos em Revistas Internacionais
I&D CQC - Artigos em Revistas Internacionais

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