Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/107427
DC FieldValueLanguage
dc.contributor.authorCorreia-Barros, Gabriela-
dc.contributor.authorSerambeque, Beatriz-
dc.contributor.authorCarvalho, Maria João-
dc.contributor.authorMarto, Carlos Miguel-
dc.contributor.authorPineiro, Marta-
dc.contributor.authorPinho e Melo, Teresa M. V. D.-
dc.contributor.authorBotelho, M. Filomena-
dc.contributor.authorLaranjo, Mafalda-
dc.date.accessioned2023-07-11T08:56:46Z-
dc.date.available2023-07-11T08:56:46Z-
dc.date.issued2022-05-23-
dc.identifier.issn2306-5354pt
dc.identifier.urihttps://hdl.handle.net/10316/107427-
dc.description.abstractPhotodynamic therapy (PDT) is a medical procedure useful for several benign conditions (such as wound healing and infections) and cancer. PDT is minimally invasive, presents few side effects, good scaring, and is able to minimal tissue destruction maintaining organ anatomy and function. Endoscopic access to the uterus puts PDT in the spotlight for endometrial disease treatment. This work systematically reviews the current evidence of PDT's potential and usefulness in endometrial diseases. Thus, this narrative review focused on PDT applications for endometrial disease, including reports regarding in vitro, ex vivo, animal, and clinical studies. Cell lines and primary samples were used as in vitro models of cancer, adenomyosis and endometrioses, while most animal studies focused the PDT outcomes on endometrial ablation. A few clinical attempts are known using PDT for endometrial ablation and cancer lesions. This review emphasises PDT as a promising field of research. This therapeutic approach has the potential to become an effective conservative treatment method for endometrial benign and malignant lesions. Further investigations with improved photosensitisers are highly expected.pt
dc.language.isoengpt
dc.publisherMDPIpt
dc.relationThis research was funded by the Foundation for Science and Technology (FCT), Portugal, and the European Social Fund (FSE), through a PhD fellowship awarded to Beatriz Serambeque (2020.07672.BD). Project PTDC/QUI-QOR/0103/2021 was financed by FCT, I.P./MCTES, by national funds (PIDDAC). CIBB was supported by National Funds via FCT through the Strategic Projects UID/NEU/04539/2019, UIDB/04539/2020, UIDP/04539/2020, and by COMPETE-FEDER (POCI- 01-0145-FEDER-007440). Coimbra Chemistry Centre (CQC) was supported by FCT under projects UIDB/00313/2020 and UIDP/00313/2020.pt
dc.rightsopenAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt
dc.subjectendometrial neoplasmspt
dc.subjectendometriumpt
dc.subjectmodelspt
dc.subjectanimalpt
dc.subjectphotochemotherapypt
dc.subjectphotodynamic therapypt
dc.subjecttherapeuticspt
dc.titleApplications of Photodynamic Therapy in Endometrial Diseasespt
dc.typearticle-
degois.publication.firstPage226pt
degois.publication.issue5pt
degois.publication.titleBioengineeringpt
dc.peerreviewedyespt
dc.identifier.doi10.3390/bioengineering9050226pt
degois.publication.volume9pt
dc.date.embargo2022-05-23*
uc.date.periodoEmbargo0pt
item.grantfulltextopen-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.openairetypearticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextCom Texto completo-
crisitem.author.researchunitICBR Coimbra Institute for Clinical and Biomedical Research-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.parentresearchunitFaculty of Medicine-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.orcid0000-0001-9269-5417-
crisitem.author.orcid0000-0002-7460-3758-
crisitem.author.orcid0000-0003-3256-4954-
crisitem.author.orcid0000-0001-7202-1650-
crisitem.author.orcid0000-0003-0689-6007-
Appears in Collections:I&D CQC - Artigos em Revistas Internacionais
I&D ICBR - Artigos em Revistas Internacionais
I&D CIBB - Artigos em Revistas Internacionais
FMUC Medicina - Artigos em Revistas Internacionais
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