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Title: Beneficial Effects of Dietary Polyphenols on Gut Microbiota and Strategies to Improve Delivery Efficiency
Authors: Kumar Singh, Amit
Cabral, Célia 
Kumar, Ramesh
Ganguly, Risha
Kumar Rana, Harvesh
Gupta, Ashutosh
Rosaria Lauro, Maria
Carbone, Claudia 
Reis, Flávio 
Pandey, Abhay K.
Keywords: dietary polyphenols; gut microbiota; dysbiosis; gastrointestinal diseases; metabolic disorders; delivery systems
Issue Date: 13-Sep-2019
Publisher: MDPI
Project: A.K.S., R.K. and R.G. acknowledge the support from CSIR-New Delhi India in the form of Senior/Junior research fellowship. A.K.S., R.K., R.G., H.K.R., A.G. and A.K.P. also acknowledge DST-FIST India and UGC-SAP India for the financial support provided to Department of Biochemistry, University of Allahabad India. This work was also supported by European Regional Development Fund (FEDER), through Programa Operacional Factores de Competitividade COMPETE2020 (CENTRO-01-0145-FEDER-000012-HealthyAging2020) and by National funds via Portuguese Science and Technology Foundation (FCT): Strategic Projects (UID/NEU/04539/2013 and UID/NEU/04539/2019), and PTDC/SAU-NUT/31712/2017, as well as by COMPETE-FEDER funds (POCI-01-0145-FEDER-007440 and POCI-01-0145-FEDER-031712). 
Serial title, monograph or event: Nutrients
Volume: 11
Issue: 9
Abstract: The human intestine contains an intricate ecological community of dwelling bacteria, referred as gut microbiota (GM), which plays a pivotal role in host homeostasis. Multiple factors could interfere with this delicate balance, including genetics, age, antibiotics, as well as environmental factors, particularly diet, thus causing a disruption of microbiota equilibrium (dysbiosis). Growing evidences support the involvement of GM dysbiosis in gastrointestinal (GI) and extra-intestinal cardiometabolic diseases, namely obesity and diabetes. This review firstly overviews the role of GM in health and disease, then critically reviews the evidences regarding the influence of dietary polyphenols in GM based on preclinical and clinical data, ending with strategies under development to improve efficiency of delivery. Although the precise mechanisms deserve further clarification, preclinical and clinical data suggest that dietary polyphenols present prebiotic properties and exert antimicrobial activities against pathogenic GM, having benefits in distinct disorders. Specifically, dietary polyphenols have been shown ability to modulate GM composition and function, interfering with bacterial quorum sensing, membrane permeability, as well as sensitizing bacteria to xenobiotics. In addition, can impact on gut metabolism and immunity and exert anti-inflammatory properties. In order to overcome the low bioavailability, several different approaches have been developed, aiming to improve solubility and transport of dietary polyphenols throughout the GI tract and deliver in the targeted intestinal regions. Although more research is still needed, particularly translational and clinical studies, the biotechnological progresses achieved during the last years open up good perspectives to, in a near future, be able to improve the use of dietary polyphenols modulating GM in a broad range of disorders characterized by a dysbiotic phenotype.
ISSN: 2072-6643
DOI: 10.3390/nu11092216
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
I&D ICBR - Artigos em Revistas Internacionais

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