Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/107172
Título: | Bioinspired-Metalloporphyrin Magnetic Nanocomposite as a Reusable Catalyst for Synthesis of Diastereomeric (-)-Isopulegol Epoxide: Anticancer Activity Against Human Osteosarcoma Cells (MG-63) | Autor: | Dias, Lucas D. Batista de Carvalho, Ana L. M. Pinto, Sara M. A. Aquino, Gilberto L. B. Calvete, Mário J. F. Rossi, Liane M. Marques, Maria Paula Pereira, Mariette M. |
Palavras-chave: | hybrid magnetic nanoparticles; manganese(III) porphyrin; epoxidation; molecular oxygen; terpene; isopulegol; anticancer activity; human osteosarcoma | Data: | 24-Dez-2018 | Editora: | MDPI | Projeto: | PEst-OE/QUI/UI0313/2014 UID/MULTI/00070/2013 CNPq – Brasil (Conselho Nacional de Desenvolvimento Científico e Tecnológico) - PhD grant 232620/2014-8/GDE ReNATURE – CENTRO-01-0145-FEDER-000007 SFRH/BPD/84619/2012 SFRH/BPD/99698/2014 |
Título da revista, periódico, livro ou evento: | Molecules | Volume: | 24 | Número: | 1 | Resumo: | In the present study, we developed a green epoxidation approach for the synthesis of the diastereomers of (-)-isopulegol benzyl ether epoxide using molecular oxygen as the oxidant and a hybrid manganese(III)-porphyrin magnetic reusable nanocomposite as the catalyst. High activity, selectivity, and stability were obtained, with up to four recycling cycles without the loss of activity and selectivity for epoxide. The anticancer effect of the newly synthesized isopulegol epoxide diastereomers was evaluated on a human osteosarcoma cell line (MG-63); both diastereomers showed similar in vitro potency. The measured IC50 values were significantly lower than those reported for other monoterpene analogues, rendering these epoxide isomers as promising anti-tumor agents against low prognosis osteosarcoma. | URI: | https://hdl.handle.net/10316/107172 | ISSN: | 1420-3049 | DOI: | 10.3390/molecules24010052 | Direitos: | openAccess |
Aparece nas coleções: | FCTUC Química - Artigos em Revistas Internacionais I&D CQC - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Citações SCOPUSTM
11
Visto em 30/set/2024
Citações WEB OF SCIENCETM
14
Visto em 2/out/2024
Visualizações de página
104
Visto em 1/out/2024
Downloads
34
Visto em 1/out/2024
Google ScholarTM
Verificar
Altmetric
Altmetric
Este registo está protegido por Licença Creative Commons