Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/106654
Título: | Identification of new targets of S-nitrosylation in neural stem cells by thiol redox proteomics | Autor: | Santos, Ana Isabel Lourenço, Ana Sofia Simão, Sónia Marques da Silva, Dorinda Santos, Daniela Filipa Onofre de Carvalho, Ana Paula Pereira, Ana Catarina Izquierdo-Álvarez, Alicia Ramos, Elena Morato, Esperanza Marina, Anabel Martínez-Ruiz, Antonio Araújo, Inês Maria |
Palavras-chave: | Nitric oxide S-nitrosylation; Neurogenesis; Neural stem cells; Neurogenesis Seizures; Hippocampus | Data: | Mai-2020 | Editora: | Elsevier | Projeto: | SFRH/BD/77903/2011 SFRH/BD/79308/2011 PTDC/QUI-QFI/29319/2017 PTDC/NEU-OSD/0473/2012 UID/BIM/04773/2019 |
Título da revista, periódico, livro ou evento: | Redox Biology | Volume: | 32 | Resumo: | Nitric oxide (NO) is well established as a regulator of neurogenesis. NO increases the proliferation of neural stem cells (NSC), and is essential for hippocampal injury-induced neurogenesis following an excitotoxic lesion. One of the mechanisms underlying non-classical NO cell signaling is protein S-nitrosylation. This post-translational modification consists in the formation of a nitrosothiol group (R-SNO) in cysteine residues, which can promote formation of other oxidative modifications in those cysteine residues. S-nitrosylation can regulate many physiological processes, including neuronal plasticity and neurogenesis. In this work, we aimed to identify S-nitrosylation targets of NO that could participate in neurogenesis. In NSC, we identified a group of proteins oxidatively modified using complementary techniques of thiol redox proteomics. S-nitrosylation of some of these proteins was confirmed and validated in a seizure mouse model of hippocampal injury and in cultured hippocampal stem cells. The identified S-nitrosylated proteins are involved in the ERK/MAPK pathway and may be important targets of NO to enhance the proliferation of NSC. | URI: | https://hdl.handle.net/10316/106654 | ISSN: | 22132317 | DOI: | 10.1016/j.redox.2020.101457 | Direitos: | openAccess |
Aparece nas coleções: | I&D CNC - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Identification of new targets of S-nitrosylation in neural stem cells by thiol redox proteomics.pdf | 2.04 MB | Adobe PDF | Ver/Abrir |
Citações SCOPUSTM
6
Visto em 30/set/2024
Citações WEB OF SCIENCETM
6
Visto em 2/out/2024
Visualizações de página
81
Visto em 16/out/2024
Downloads
18
Visto em 16/out/2024
Google ScholarTM
Verificar
Altmetric
Altmetric
Este registo está protegido por Licença Creative Commons