Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/106629
DC FieldValueLanguage
dc.contributor.authorFerreira, Sílvia-
dc.contributor.authorPiedade, A. P.-
dc.date.accessioned2023-04-13T09:45:41Z-
dc.date.available2023-04-13T09:45:41Z-
dc.date.issued2020-04-05-
dc.identifier.issn2073-4360pt
dc.identifier.urihttps://hdl.handle.net/10316/106629-
dc.description.abstractThe study of interfaces between engineered surfaces and prokaryotic cells is a subject whose actual relevance has been reinforced by the current outbreaks due to unknown viruses and antibiotic-resistant bacteria. Studies aiming at the development of antibacterial surfaces are based on two pillars: surface chemistry or topographical cues. This work reports the study of only the topographic aspect by the development of thin films of polyamide, which present attractive surface chemistry for bacterial adhesion. The same chemistry with only nano- or hierarchical nano- and micro-topography that mimics the extracellular matrix is obtained by sputter-depositing the thin films onto Si and polydimethylsiloxane (PDMS), respectively. The surface average roughness of the Si-modified surfaces was around 1 nm, while the hierarchical topography presented values from 750 to 1000 nm, with wavelengths and amplitudes ranging from 15-30 µm and 1-3 µm, respectively, depending on the deposition parameters. The surface topography, wettability, surface charge, and mechanical properties were determined and related to interface performance with two Gram+ and two Gram- bacterial strains. The overall results show that surfaces with only nano-topographic features present less density of bacteria, regardless of their cell wall composition or cell shape, if the appropriate surface chemistry is present.pt
dc.language.isoengpt
dc.publisherMDPIpt
dc.relationUID/EMS/00285/2020pt
dc.relationPOCI-01-0247-FEDER-024533pt
dc.rightsopenAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt
dc.subjectnano-micro-wrinklespt
dc.subjecthierarchical topographiespt
dc.subjectmimic extracellular matricespt
dc.subjectpolyamide thin filmspt
dc.subjectprokaryotic cellspt
dc.titleInfluence of Extracellular Mimicked Hierarchical Nano-Micro-Topography on the Bacteria/Abiotic Interfacept
dc.typearticle-
degois.publication.firstPage828pt
degois.publication.issue4pt
degois.publication.titlePolymerspt
dc.peerreviewedyespt
dc.identifier.doi10.3390/polym12040828pt
degois.publication.volume12pt
dc.date.embargo2020-04-05*
uc.date.periodoEmbargo0pt
item.grantfulltextopen-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.openairetypearticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextCom Texto completo-
crisitem.author.orcid0000-0001-5549-5168-
crisitem.author.orcid0000-0002-1588-0640-
crisitem.project.grantnoinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID/EMS/00285/2020/PT/Centre for Mechanical Engineering-
Appears in Collections:I&D CEMMPRE - Artigos em Revistas Internacionais
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