Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/106369
Title: Photocurable Polymeric Blends for Surgical Application
Authors: Cernadas, Teresa 
Santos, Marta 
Miguel, Sónia P.
Correia, Ilídio J. 
Alves, Patrícia 
Ferreira, Paula 
Keywords: photocuring; polymeric blends; bioadhesive; biocompatibility; antibacterial activity
Issue Date: 12-Dec-2020
Publisher: MDPI
Project: FCT Researcher—grant number IF/01432/2015 
project ZAPGO—grant number PTDC/NAN-MAT/28989/2017) 
project INEYE—grant number PTDC/EMD-EMD/31462/2017 
UIDB/00102/2020 
UID/QUI/00313/2019 
RECI/QEQ-QFI/0168/2012 
CENTRO-07-CT62-FEDER-002012 
Serial title, monograph or event: Materials
Volume: 13
Issue: 24
Abstract: The preparation of photocrosslinkable bioadhesives synthesized from oligomers of lactic acid and polycaprolactone (PCL), both functionalized with 2-isocyanoethyl acrylate (AOI), were studied. The obtained modified macromers of LA-AOI (mLA) and PCL-AOI (mCL) were chemically characterized by 1H NMR and used to formulate polymeric blends with different mass proportions, 1:1, 1:2 and 2:1, respectively. Subsequently, the produced blends were crosslinked, considering two UV irradiation times: 30 and 120 s. After their production, the thermal and mechanical properties of bioadhesives were assessed, where upon the rheology, gel content, hydrolytic degradation and dynamic contact angles were determined. Furthermore, the cytotoxic profile of bioadhesives was evaluated in contact with human dermal fibroblasts cells, whereas their antibacterial effect was studied monitoring Escherichia coli and S. aureus growth. Overall, flexible and resistant films were obtained, presenting promising features to be used as surgical bioadhesives.
URI: https://hdl.handle.net/10316/106369
ISSN: 1996-1944
DOI: 10.3390/ma13245681
Rights: openAccess
Appears in Collections:I&D CIEPQPF - Artigos em Revistas Internacionais

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