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Title: Dual Imaging Gold Nanoplatforms for Targeted Radiotheranostics
Authors: Silva, Francisco
Paulo, António
Pallier, Agnès
Même, Sandra
Tóth, Éva
Gano, Lurdes
Marques, Fernanda 
Geraldes, Carlos F. G. C. 
Castro, M. Margarida C. A. 
Cardoso, Ana Maria S. 
Jurado, Amália 
López-Larrubia, Pilar
Lacerda, Sara
Campello, Maria Paula Cabral
Keywords: gold nanoparticles; multimodality; MRI; SPECT; bombesin; PC3 tumor; radiosensitization
Issue Date: 22-Jan-2020
Publisher: MDPI
Project: FCT - EXCL/QEQ-MED/0233/2012 
Ministry of Economy, Industry and Competitiviy for SAF2017-83043-R 
Comunity of Madrid, FEDER and FSE for S2017/BMD-3688 
Serial title, monograph or event: Materials
Volume: 13
Issue: 3
Abstract: Gold nanoparticles (AuNPs) are interesting for the design of new cancer theranostic tools, mainly due to their biocompatibility, easy molecular vectorization, and good biological half-life. Herein, we report a gold nanoparticle platform as a bimodal imaging probe, capable of coordinating Gd3+ for Magnetic Resonance Imaging (MRI) and 67Ga3+ for Single Photon Emission Computed Tomography (SPECT) imaging. Our AuNPs carry a bombesin analogue with affinity towards the gastrin releasing peptide receptor (GRPr), overexpressed in a variety of human cancer cells, namely PC3 prostate cancer cells. The potential of these multimodal imaging nanoconstructs was thoroughly investigated by the assessment of their magnetic properties, in vitro cellular uptake, biodistribution, and radiosensitisation assays. The relaxometric properties predict a potential T1- and T2- MRI application. The promising in vitro cellular uptake of 67Ga/Gd-based bombesin containing particles was confirmed through biodistribution studies in tumor bearing mice, indicating their integrity and ability to target the GRPr. Radiosensitization studies revealed the therapeutic potential of the nanoparticles. Moreover, the DOTA chelating unit moiety versatility gives a high theranostic potential through the coordination of other therapeutically interesting radiometals. Altogether, our nanoparticles are interesting nanomaterial for theranostic application and as bimodal T1- and T2- MRI / SPECT imaging probes.
ISSN: 1996-1944
DOI: 10.3390/ma13030513
Rights: openAccess
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais
I&D ICNAS - Artigos em Revistas Internacionais
I&D CIBIT - Artigos em Revistas Internacionais
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I&D CQC - Artigos em Revistas Internacionais

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