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Title: | Antitumour Potential of Gigartina pistillata Carrageenans against Colorectal Cancer Stem Cell-Enriched Tumourspheres | Authors: | Cotas, João Marques, Vanda Afonso, Marta B. Rodrigues, Cecília M. P. Pereira, Leonel |
Keywords: | antitumour activity; carrageenan; colorectal cancer; cancer stem cells | Issue Date: | 12-Jan-2020 | Publisher: | MDPI | Serial title, monograph or event: | Marine Drugs | Volume: | 18 | Issue: | 1 | Abstract: | Gigartina pistillata is a red seaweed common in Figueira da Foz, Portugal. Here, the antitumour potential of G. pistillata carrageenan, with a known variable of the life cycle, the female gametophyte (FG) and tetrasporophyte (T) was evaluated against colorectal cancer stem cell (CSC) -enriched tumourspheres. FTIR-ATR analysis of G. pistillata carrageenan extracts indicated differences between life cycle phases, being FG a κ/ι hybrid carrageenan and T a ʎ/ξ hybrid. Both carrageenan extracts presented IC50 values inferior to 1 μg/mL in HT29-derived CSC-enriched tumourspheres, as well as reduced tumoursphere area. The two extracts were also effective at reducing cellular viability in SW620- and SW480-derived tumourspheres. These results indicate that carrageenans extracted from two G. pistillata life cycle phases have antitumour potential against colorectal cancer stem-like cells, specially the T carrageenan. | URI: | https://hdl.handle.net/10316/106352 | ISSN: | 1660-3397 | DOI: | 10.3390/md18010050 | Rights: | openAccess |
Appears in Collections: | I&D MARE - Artigos em Revistas Internacionais FCTUC Ciências da Vida - Artigos em Revistas Internacionais |
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