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Title: Antitumour Potential of Gigartina pistillata Carrageenans against Colorectal Cancer Stem Cell-Enriched Tumourspheres
Authors: Cotas, João 
Marques, Vanda
Afonso, Marta B.
Rodrigues, Cecília M. P.
Pereira, Leonel 
Keywords: antitumour activity; carrageenan; colorectal cancer; cancer stem cells
Issue Date: 12-Jan-2020
Publisher: MDPI
Serial title, monograph or event: Marine Drugs
Volume: 18
Issue: 1
Abstract: Gigartina pistillata is a red seaweed common in Figueira da Foz, Portugal. Here, the antitumour potential of G. pistillata carrageenan, with a known variable of the life cycle, the female gametophyte (FG) and tetrasporophyte (T) was evaluated against colorectal cancer stem cell (CSC) -enriched tumourspheres. FTIR-ATR analysis of G. pistillata carrageenan extracts indicated differences between life cycle phases, being FG a κ/ι hybrid carrageenan and T a ʎ/ξ hybrid. Both carrageenan extracts presented IC50 values inferior to 1 μg/mL in HT29-derived CSC-enriched tumourspheres, as well as reduced tumoursphere area. The two extracts were also effective at reducing cellular viability in SW620- and SW480-derived tumourspheres. These results indicate that carrageenans extracted from two G. pistillata life cycle phases have antitumour potential against colorectal cancer stem-like cells, specially the T carrageenan.
ISSN: 1660-3397
DOI: 10.3390/md18010050
Rights: openAccess
Appears in Collections:I&D MARE - Artigos em Revistas Internacionais
FCTUC Ciências da Vida - Artigos em Revistas Internacionais

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