Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/106121
Title: Non-invasive Transdermal Delivery of Human Insulin Using Ionic Liquids: In vitro Studies
Authors: Jorge, Ludmilla R.
Harada, Liliam K.
Silva, Erica C.
Campos, Welida F.
Moreli, Fernanda C.
Shimamoto, Gustavo
Pereira, Jorge F. B. 
Oliveira, José M
Tubino, Matthieu
Vila, Marta M. D. C.
Balcão, Victor M.
Keywords: human insulin; ionic liquids; choline geranate; choline oleate; transdermal permeation; chemical and biological characterization
Issue Date: 2020
Publisher: Frontiers Media S.A.
metadata.degois.publication.title: Frontiers in Pharmacology
metadata.degois.publication.volume: 11
Abstract: In this research project, synthesis and characterization of ionic liquids and their subsequent utilization as facilitators of transdermal delivery of human insulin was pursued. Choline geranate and choline oleate ionic liquids (and their deep eutectic solvents) were produced and characterized by nuclear magnetic resonance (1H NMR), water content, oxidative stability, cytotoxicity and genotoxicity assays, and ability to promote transdermal protein permeation. The results gathered clearly suggest that all ionic liquids were able to promote/facilitate transdermal permeation of insulin, although to various extents. In particular, choline geranate 1:2 combined with its virtually nil cyto- and geno-toxicity was chosen to be incorporated in a biopolymeric formulation making it a suitable facilitator aiming at transdermal delivery of insulin.
URI: https://hdl.handle.net/10316/106121
ISSN: 1663-9812
DOI: 10.3389/fphar.2020.00243
Rights: openAccess
Appears in Collections:I&D CERES - Artigos em Revistas Internacionais

Show full item record

SCOPUSTM   
Citations

51
checked on Nov 4, 2024

WEB OF SCIENCETM
Citations

49
checked on Nov 2, 2024

Page view(s)

83
checked on Oct 30, 2024

Download(s)

48
checked on Oct 30, 2024

Google ScholarTM

Check

Altmetric

Altmetric


This item is licensed under a Creative Commons License Creative Commons