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Title: Strategies for Cancer Immunotherapy Using Induced Pluripotency Stem Cells-Based Vaccines
Authors: Bernardes de Jesus, Bruno
Neves, Bruno Miguel 
Ferreira, Manuela 
Nóbrega-Pereira, Sandrina
Keywords: iPSCs; cancer; reprogramming; immunotherapy; neoantigens; vaccines
Issue Date: 30-Nov-2020
Publisher: MDPI
Project: LISBOA-01-0145-FEDER-028534 
UIDB/04501/2020 to iBiMED 
European Commission (ERA-CVD Joint Call 2018, grant#INNOVATION) through FCT and the Portuguese Ministry of Health, through the Directorate General of Health (DGS) 
Serial title, monograph or event: Cancers
Volume: 12
Issue: 12
Abstract: Despite improvements in cancer therapy, metastatic solid tumors remain largely incurable. Immunotherapy has emerged as a pioneering and promising approach for cancer therapy and management, and in particular intended for advanced tumors unresponsive to current therapeutics. In cancer immunotherapy, components of the immune system are exploited to eliminate cancer cells and treat patients. The recent clinical successes of immune checkpoint blockade and chimeric antigen receptor T cell therapies represent a turning point in cancer treatment. Despite their potential success, current approaches depend on efficient tumor antigen presentation which are often inaccessible, and most tumors turn refractory to current immunotherapy. Patient-derived induced pluripotent stem cells (iPSCs) have been shown to share several characteristics with cancer (stem) cells (CSCs), eliciting a specific anti-tumoral response when injected in rodent cancer models. Indeed, artificial cellular reprogramming has been widely compared to the biogenesis of CSCs. Here, we will discuss the state-of-the-art on the potential implication of cellular reprogramming and iPSCs for the design of patient-specific immunotherapeutic strategies, debating the similarities between iPSCs and cancer cells and introducing potential strategies that could enhance the efficiency and therapeutic potential of iPSCs-based cancer vaccines.
ISSN: 2072-6694
DOI: 10.3390/cancers12123581
Rights: openAccess
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais

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