Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/10566
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dc.contributor.authorSarmento, Bruno-
dc.contributor.authorRibeiro, António-
dc.contributor.authorVeiga, Francisco-
dc.contributor.authorFerreira, Domingos-
dc.contributor.authorNeufeld, Ronald-
dc.date.accessioned2009-07-08T13:09:57Z-
dc.date.available2009-07-08T13:09:57Z-
dc.date.issued2007-10-08-
dc.identifier.citationBiomacromolecules. 8:10 (2007) 3054-3060en_US
dc.identifier.issn1525-7797-
dc.identifier.urihttp://hdl.handle.net/10316/10566-
dc.description.abstractThe pharmacological activity of insulin-loaded dextran sulfate/chitosan nanoparticles was evaluated following oral dosage in diabetic rats. Nanoparticles were mucoadhesive and negatively charged with a mean size of 500 nm, suitable for uptake within the gastrointestinal tract. Insulin association efficiency was over 70% and was released in a pH-dependent manner under simulated gastrointestinal conditions. Orally delivered nanoparticles lowered basal serum glucose levels in diabetic rats around 35% with 50 and 100 IU/kg doses sustaining hypoglycemia over 24 h. Pharmacological availability was 5.6 and 3.4% for the 50 and 100 IU/kg doses, respectively, a significant increase over 1.6%, determined for oral insulin alone in solution. Confocal microscopic examinations of FITC-labeled insulin nanoparticles showed adhesion to rat intestinal epithelium, and internalization of insulin within the intestinal mucosa. Encapsulation of insulin into dextran sulfate/chitosan nanoparticles was a key factor in the improvement of the bioavailability of its oral delivery over insulin solution.en_US
dc.language.isoengen_US
dc.publisherAmerican Chemical Societyen_US
dc.rightsopenAccesseng
dc.titleOral Bioavailability of Insulin Contained in Polysaccharide Nanoparticlesen_US
dc.typearticleen_US
dc.identifier.doi10.1021/bm0703923-
uc.controloAutoridadeSim-
item.fulltextCom Texto completo-
item.grantfulltextopen-
item.languageiso639-1en-
Appears in Collections:FFUC- Artigos em Revistas Internacionais
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