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https://hdl.handle.net/10316/10566
Title: | Oral Bioavailability of Insulin Contained in Polysaccharide Nanoparticles | Authors: | Sarmento, Bruno Ribeiro, António Veiga, Francisco Ferreira, Domingos Neufeld, Ronald |
Issue Date: | 8-Oct-2007 | Publisher: | American Chemical Society | Citation: | Biomacromolecules. 8:10 (2007) 3054-3060 | Abstract: | The pharmacological activity of insulin-loaded dextran sulfate/chitosan nanoparticles was evaluated following oral dosage in diabetic rats. Nanoparticles were mucoadhesive and negatively charged with a mean size of 500 nm, suitable for uptake within the gastrointestinal tract. Insulin association efficiency was over 70% and was released in a pH-dependent manner under simulated gastrointestinal conditions. Orally delivered nanoparticles lowered basal serum glucose levels in diabetic rats around 35% with 50 and 100 IU/kg doses sustaining hypoglycemia over 24 h. Pharmacological availability was 5.6 and 3.4% for the 50 and 100 IU/kg doses, respectively, a significant increase over 1.6%, determined for oral insulin alone in solution. Confocal microscopic examinations of FITC-labeled insulin nanoparticles showed adhesion to rat intestinal epithelium, and internalization of insulin within the intestinal mucosa. Encapsulation of insulin into dextran sulfate/chitosan nanoparticles was a key factor in the improvement of the bioavailability of its oral delivery over insulin solution. | URI: | https://hdl.handle.net/10316/10566 | ISSN: | 1525-7797 | DOI: | 10.1021/bm0703923 | Rights: | openAccess |
Appears in Collections: | FFUC- Artigos em Revistas Internacionais |
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Oral Bioavailability of Insulin Contained in Polysaccharide Nanoparticles.pdf | 370.36 kB | Adobe PDF | View/Open |
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