Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/105526
Title: | The role of mouse models in colorectal cancer research-The need and the importance of the orthotopic models | Authors: | Oliveira, Rui C. Abrantes, Ana Margarida Tralhão, José Guilherme Botelho, Maria Filomena |
Keywords: | colorectal cancer; mouse model; orthotopic model | Issue Date: | Mar-2020 | Publisher: | John Wiley and Sons Inc | Serial title, monograph or event: | Animal Models and Experimental Medicine | Volume: | 3 | Issue: | 1 | Abstract: | Colorectal cancer is a worldwide health burden, with high incidence and mortality, especially in the advanced stages of the disease. Preclinical models are very important and valuable to discover and validate early and specific biomarkers as well as new therapeutic targets. In order to accomplish that, the animal models must replicate the clinical evolution of the disease in all of its phases. In this article, we review the existent mouse models, with their strengths and weaknesses in the replication of human cancer disease progression, with major focus on orthotopic models. | URI: | https://hdl.handle.net/10316/105526 | ISSN: | 2576-2095 2576-2095 |
DOI: | 10.1002/ame2.12102 | Rights: | openAccess |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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Anim Models and Exp Med - 2020 - Oliveira - The role of mouse models in colorectal cancer research The need and the.pdf | 1.09 MB | Adobe PDF | View/Open |
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