Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/105526
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Oliveira, Rui C. | - |
dc.contributor.author | Abrantes, Ana Margarida | - |
dc.contributor.author | Tralhão, José Guilherme | - |
dc.contributor.author | Botelho, Maria Filomena | - |
dc.date.accessioned | 2023-03-06T10:15:28Z | - |
dc.date.available | 2023-03-06T10:15:28Z | - |
dc.date.issued | 2020-03 | - |
dc.identifier.issn | 2576-2095 | pt |
dc.identifier.issn | 2576-2095 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/105526 | - |
dc.description.abstract | Colorectal cancer is a worldwide health burden, with high incidence and mortality, especially in the advanced stages of the disease. Preclinical models are very important and valuable to discover and validate early and specific biomarkers as well as new therapeutic targets. In order to accomplish that, the animal models must replicate the clinical evolution of the disease in all of its phases. In this article, we review the existent mouse models, with their strengths and weaknesses in the replication of human cancer disease progression, with major focus on orthotopic models. | pt |
dc.language.iso | eng | pt |
dc.publisher | John Wiley and Sons Inc | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | colorectal cancer | pt |
dc.subject | mouse model | pt |
dc.subject | orthotopic model | pt |
dc.title | The role of mouse models in colorectal cancer research-The need and the importance of the orthotopic models | pt |
dc.type | article | - |
degois.publication.firstPage | 1 | pt |
degois.publication.lastPage | 8 | pt |
degois.publication.issue | 1 | pt |
degois.publication.title | Animal Models and Experimental Medicine | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1002/ame2.12102 | pt |
degois.publication.volume | 3 | pt |
dc.date.embargo | 2020-03-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0002-7202-8059 | - |
crisitem.author.orcid | 0000-0002-1864-132X | - |
crisitem.author.orcid | 0000-0001-7202-1650 | - |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
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Anim Models and Exp Med - 2020 - Oliveira - The role of mouse models in colorectal cancer research The need and the.pdf | 1.09 MB | Adobe PDF | View/Open |
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This item is licensed under a Creative Commons License