Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/105457
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Geva, Michal | - |
dc.contributor.author | Gershoni-Emek, Noga | - |
dc.contributor.author | Naia, Luana | - |
dc.contributor.author | Ly, Philip | - |
dc.contributor.author | Mota, Sandra | - |
dc.contributor.author | Rego, Ana Cristina | - |
dc.contributor.author | Hayden, Michael R. | - |
dc.contributor.author | Levin, Leonard A. | - |
dc.date.accessioned | 2023-03-01T10:14:56Z | - |
dc.date.available | 2023-03-01T10:14:56Z | - |
dc.date.issued | 2021-11-09 | - |
dc.identifier.issn | 2045-2322 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/105457 | - |
dc.description.abstract | Optic neuropathies such as glaucoma are characterized by retinal ganglion cell (RGC) degeneration and death. The sigma-1 receptor (S1R) is an attractive target for treating optic neuropathies as it is highly expressed in RGCs, and its absence causes retinal degeneration. Activation of the S1R exerts neuroprotective effects in models of retinal degeneration. Pridopidine is a highly selective and potent S1R agonist in clinical development. We show that pridopidine exerts neuroprotection of retinal ganglion cells in two different rat models of glaucoma. Pridopidine strongly binds melanin, which is highly expressed in the retina. This feature of pridopidine has implications to its ocular distribution, bioavailability, and effective dose. Mitochondria dysfunction is a key contributor to retinal ganglion cell degeneration. Pridopidine rescues mitochondrial function via activation of the S1R, providing support for the potential mechanism driving its neuroprotective effect in retinal ganglion cells. | pt |
dc.language.iso | eng | pt |
dc.publisher | Springer Nature | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject.mesh | Animals | pt |
dc.subject.mesh | Disease Models, Animal | pt |
dc.subject.mesh | Dose-Response Relationship, Drug | pt |
dc.subject.mesh | Glaucoma | pt |
dc.subject.mesh | Mitochondria | pt |
dc.subject.mesh | Neuroprotective Agents | pt |
dc.subject.mesh | Piperidines | pt |
dc.subject.mesh | Rats | pt |
dc.subject.mesh | Reactive Oxygen Species | pt |
dc.subject.mesh | Receptors, sigma | pt |
dc.subject.mesh | Retinal Ganglion Cells | pt |
dc.title | Neuroprotection of retinal ganglion cells by the sigma-1 receptor agonist pridopidine in models of experimental glaucoma | pt |
dc.type | article | - |
degois.publication.firstPage | 21975 | pt |
degois.publication.issue | 1 | pt |
degois.publication.title | Scientific Reports | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1038/s41598-021-01077-w | pt |
degois.publication.volume | 11 | pt |
dc.date.embargo | 2021-11-09 | * |
uc.date.periodoEmbargo | 0 | pt |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
item.fulltext | Com Texto completo | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0002-0886-4634 | - |
crisitem.author.orcid | 0000-0001-9623-5012 | - |
crisitem.author.orcid | 0000-0003-0700-3776 | - |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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Neuroprotection-of-retinal-ganglion-cells-by-the-sigma1-receptor-agonist-pridopidine-in-models-of-experimental-glaucomaScientific-Reports.pdf | 9.74 MB | Adobe PDF | View/Open |
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